FLUX DISTRIBUTION IN BACILLUS SUBTILIS: INSPECTION ON PLURALITY OF OPTIMAL SOLUTIONS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOTAMEDIAN EHSAN; NAEIMPOOR FERESHTEH

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Biotechnology Year:2011 | Volume:9 | Issue:4 Page(s): 260-266

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,227

Download:

160

Cites:

Information Journal Paper

Title

FLUX DISTRIBUTION IN BACILLUS SUBTILIS: INSPECTION ON PLURALITY OF OPTIMAL SOLUTIONS

Author(s)

MOTAMEDIAN EHSAN | NAEIMPOOR FERESHTEH | Issue Writer Certificate

Keywords

BACILLUS SUBTILISQ2

FLUX BALANCE ANALYSISQ2

METABOLIC REACTION NETWORKQ2

MULTIPLE OPTIMAL FLUX DISTRIBUTIONQ2

REDUCED COST COEFFICIENTQ2

MIXED INTEGER LINEAR PROGRAMMINGQ2

Abstract

Linear programming problems with alternate solutions are challenging due to the choice of multiple strategies resulting in the same optimal value of the objective function. However, searching for these solutions is a tedious task, especially when using MIXED INTEGER LINEAR PROGRAMMING (MILP), as previously applied to metabolic models. Therefore, judgment on plurality of optimal metabolic flux distributions (solutions) a priori to applying MILP approach could prevent unnecessary computations. In this work for the first time, the REDUCED COST COEFFICIENTs for the non-basic variables in a current solution of a metabolic model were utilized to inspect the possibility of MULTIPLE OPTIMAL FLUX DISTRIBUTIONs.If there exists at least one non-basic variable with zero REDUCED COST COEFFICIENT, multiplicity of optimal solution may occur where MILP can be used to find these solutions. This approach was implemented on a metabolic network of BACILLUS SUBTILIS aiming to reduce the cell energy requirement. Solving the model at fixed specific growth rate of 0.4 1/h resulted in minimum energy requirement of 12.67 mmol/g-h.Inspection of REDUCED COST COEFFICIENTs showed that six non-basic variables had zero REDUCED COST COEFFICIENTs at current solution, which shows that there can exist multiple optimal solutions. Subsequently, by applying MILP, five optimal flux distributions at minimized energy requirement were identified, among which one showing no acid production and minimum glucose consumption rate was selected as the superior solution.

Cites

No record.

References

No record.

Cite

APA: Copy

MOTAMEDIAN, EHSAN, & NAEIMPOOR, FERESHTEH. (2011). FLUX DISTRIBUTION IN BACILLUS SUBTILIS: INSPECTION ON PLURALITY OF OPTIMAL SOLUTIONS. IRANIAN JOURNAL OF BIOTECHNOLOGY, 9(4), 260-266. SID. https://sid.ir/paper/139339/en

Vancouver: Copy

MOTAMEDIAN EHSAN, NAEIMPOOR FERESHTEH. FLUX DISTRIBUTION IN BACILLUS SUBTILIS: INSPECTION ON PLURALITY OF OPTIMAL SOLUTIONS. IRANIAN JOURNAL OF BIOTECHNOLOGY[Internet]. 2011;9(4):260-266. Available from: https://sid.ir/paper/139339/en

IEEE: Copy

EHSAN MOTAMEDIAN, and FERESHTEH NAEIMPOOR, “FLUX DISTRIBUTION IN BACILLUS SUBTILIS: INSPECTION ON PLURALITY OF OPTIMAL SOLUTIONS,” IRANIAN JOURNAL OF BIOTECHNOLOGY, vol. 9, no. 4, pp. 260–266, 2011, [Online]. Available: https://sid.ir/paper/139339/en

Related Journal Papers