A STUDY ON BIOFILM FORMATION OF BACILLUS SUBTILIS ON THE SURFACE OF PHARMACEUTICAL PRODUCTS PACKAGING

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FAZLI BAZAZ B.S.; BEHRAVAN J.; NABIZADEH S.

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Journal: Iranian Journal of Basic Medical Sciences Year:2000 | Volume:3 | Issue:1 (6) Page(s): 20-26

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Title

A STUDY ON BIOFILM FORMATION OF BACILLUS SUBTILIS ON THE SURFACE OF PHARMACEUTICAL PRODUCTS PACKAGING

Author(s)

FAZLI BAZAZ B.S. | BEHRAVAN J. | NABIZADEH S. | Issue Writer Certificate

Keywords

BIOFILMQ2

BACILLUS SUBTILISQ4

GLYCOCALYXQ3

Abstract

BIOFILM formation is a major problem in different industrial fields; including pharmaceutical, agricultural and medicinal industries. It is possible to select materials for making containers with lowest probability of BIOFILM formation. In this study, the BIOFILM formation on the glass, plastic and some other materials, at 2, 6 and 10 days intervals, in nutrient broth medium, already inoculated with BACILLUS SUBTILIS, was investigated. Different temperatures for BIOFILM formation were used. Also GLYCOCALYX, developed by BIOFILM formation, quantitatively determined using a biochemical method. The results showed that BIOFILM formation was maximum at 30°C. Total counts of bacteria detached from BIOFILM, indicates that, it can develop BIOFILM on the polypropylene surface much more than the other surfaces and after 10 days, the formation of BIOFILM reached to its maximum level. Also surfaces with similar physical properties had no difference on BIOFILM formation while surfaces with different physical properties showed 10-20 times difference on BIOFILM formation. Quantitative determination of GLYCOCALYX showed that, by increasing the time, the GLYCOCALYX formation was increased and the yield was more on polypropylene surface and less on glass. The results of this study could be used in selecting the material for pharmaceutical containers.

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APA: Copy

FAZLI BAZAZ, B.S., BEHRAVAN, J., & NABIZADEH, S.. (2000). A STUDY ON BIOFILM FORMATION OF BACILLUS SUBTILIS ON THE SURFACE OF PHARMACEUTICAL PRODUCTS PACKAGING. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 3(1 (6)), 20-26. SID. https://sid.ir/paper/52412/en

Vancouver: Copy

FAZLI BAZAZ B.S., BEHRAVAN J., NABIZADEH S.. A STUDY ON BIOFILM FORMATION OF BACILLUS SUBTILIS ON THE SURFACE OF PHARMACEUTICAL PRODUCTS PACKAGING. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2000;3(1 (6)):20-26. Available from: https://sid.ir/paper/52412/en

IEEE: Copy

B.S. FAZLI BAZAZ, J. BEHRAVAN, and S. NABIZADEH, “A STUDY ON BIOFILM FORMATION OF BACILLUS SUBTILIS ON THE SURFACE OF PHARMACEUTICAL PRODUCTS PACKAGING,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 3, no. 1 (6), pp. 20–26, 2000, [Online]. Available: https://sid.ir/paper/52412/en

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