THE HYPOLIPIDEMIC EFFECTS OF ANETHUM IN NORMAL AND STREPTOZOCIN- INDUCED DIABETIC RATS

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PIRI MORTEZA; ORYAN SHAHRBANOU; SHAHIN MARYAM SADAT; NASEHI MOHAMMAD

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Journal: BIOLOGY JOURNAL Year:2009 | Volume:4 | Issue:1 Page(s): 9-20

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Title

THE HYPOLIPIDEMIC EFFECTS OF ANETHUM IN NORMAL AND STREPTOZOCIN- INDUCED DIABETIC RATS

Author(s)

PIRI MORTEZA | ORYAN SHAHRBANOU | SHAHIN MARYAM SADAT | NASEHI MOHAMMAD | Issue Writer Certificate

Keywords

ANETHUMQ3

STREPTOZOCIN- INDUCED DIABETESQ2

TRIGLYCERIDEQ3

CHOLESTEROLQ3

LIPOPROTEINSQ2

Abstract

Objective: In diabetic patient, dyslipidemia caused an increase in the risk of cardiovascular disease. The search for a new drug with the potential of reduction or regulation of serum lipid and LIPOPROTEINS has received wide attention in recent years. The present study investigated the hypolipidemic effects of ANETHUM in normal and streptozocin- induced diabetic rats.Method: Diabetes induced by streptozocin (60 mg/kg, i.p) injection. Then normal and diabetic rats treatment by oral administration of 50, 100 and 200m g/kg body wt. of ANETHUM for 21 days after which blood samples were collected following an over-night fast and the serum was separated. Then total TRIGLYCERIDE, total CHOLESTEROL and HDL-C in each serum sample were determined enzymatically using commercial Kits and serum LDL-C levels were derived using the Friedewald formula.Results: In normal rats, ANETHUM significantly decreased TRIGLYCERIDE and LDL-C and increased HDL-C but could not affect blood total CHOLESTEROL level. Results also show that ANETHUM has not antilipidemic effect on diabetic rats. Also ANETHUM decrease body weight in normal and diabetic rats.Conclusion: These results showed that ANETHUM has a strong antilipidemic effect in normal rats, but is not an effective drug for lipid lowering in Streptozocin- induced diabetic rats.

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APA: Copy

PIRI, MORTEZA, ORYAN, SHAHRBANOU, SHAHIN, MARYAM SADAT, & NASEHI, MOHAMMAD. (2009). THE HYPOLIPIDEMIC EFFECTS OF ANETHUM IN NORMAL AND STREPTOZOCIN- INDUCED DIABETIC RATS. BIOLOGY JOURNAL, 4(1), 9-20. SID. https://sid.ir/paper/141004/en

Vancouver: Copy

PIRI MORTEZA, ORYAN SHAHRBANOU, SHAHIN MARYAM SADAT, NASEHI MOHAMMAD. THE HYPOLIPIDEMIC EFFECTS OF ANETHUM IN NORMAL AND STREPTOZOCIN- INDUCED DIABETIC RATS. BIOLOGY JOURNAL[Internet]. 2009;4(1):9-20. Available from: https://sid.ir/paper/141004/en

IEEE: Copy

MORTEZA PIRI, SHAHRBANOU ORYAN, MARYAM SADAT SHAHIN, and MOHAMMAD NASEHI, “THE HYPOLIPIDEMIC EFFECTS OF ANETHUM IN NORMAL AND STREPTOZOCIN- INDUCED DIABETIC RATS,” BIOLOGY JOURNAL, vol. 4, no. 1, pp. 9–20, 2009, [Online]. Available: https://sid.ir/paper/141004/en

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