LEVAMISOLE AUGMENTS THE NATURAL CYTOTOXICITY IN MICE

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SHIRZADEH H.A.; RAFIEIAN MAHMOUD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Journal of Shahrekord University of Medical Sciences Year:2003 | Volume:5 | Issue:1 Page(s): 23-29

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Title

LEVAMISOLE AUGMENTS THE NATURAL CYTOTOXICITY IN MICE

Author(s)

SHIRZADEH H.A. | RAFIEIAN MAHMOUD | Issue Writer Certificate

Keywords

LEVAMISOLEQ4

NATURAL CYTOTOXICITYQ3

ANTI-NC-2 ANTIBODYQ4

Abstract

Murine NATURAL CYTOTOXICITY mediated by NC-1.1 and NC-2 receptors are a major component of the innate immune response to cancer. Treatment with anti-NC-2 and anti-NC-1.1 monoclonal antibodies resulted in enhanced growth of certain transplantable tumors. Therefore agents that enhance NATURAL CYTOTOXICITY could be used as anticancer drugs. We examined the immunomodulatory effect of LEVAMISOLE on NATURAL CYTOTOXICITY mediated by NC-2+ cells against the BALB/c WEHI-164 murine fibrosarcoma. Administration of LEVAMISOLE to BALB/c mice significantly enhanced in vitro splenic natural cytoxicity against 51Crlabeled WEHI-164 tumor cells. The effect was most marked 48 hours after LEVAMISOLE treatment with a dose of 10 mg/kg. This enhancement of NATURAL CYTOTOXICITY by LEVAMISOLE could be completely abrogated by pretreatment of BALB/c mice with anti-NC-2, indicating that the anti-tumor effect of LEVAMISOLE was mediated, at least partly, via NC-2+cells.

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APA: Copy

SHIRZADEH, H.A., & RAFIEIAN, MAHMOUD. (2003). LEVAMISOLE AUGMENTS THE NATURAL CYTOTOXICITY IN MICE. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 5(1), 23-29. SID. https://sid.ir/paper/359307/en

Vancouver: Copy

SHIRZADEH H.A., RAFIEIAN MAHMOUD. LEVAMISOLE AUGMENTS THE NATURAL CYTOTOXICITY IN MICE. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2003;5(1):23-29. Available from: https://sid.ir/paper/359307/en

IEEE: Copy

H.A. SHIRZADEH, and MAHMOUD RAFIEIAN, “LEVAMISOLE AUGMENTS THE NATURAL CYTOTOXICITY IN MICE,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 5, no. 1, pp. 23–29, 2003, [Online]. Available: https://sid.ir/paper/359307/en

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