THE EFFECT OF AQUEOUS EXTRACT OF MATRICARIA CHAMOMILLA ON THE ACQUISITION AND EXPRESSION OF MORPHINE INDUCED LOCOMOTOR SENSITIZATION IN ADULT MALE MICE

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ASADZADE S.

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Journal: JOURNAL OF VETERINARY MICROBIOLOGY Year:2011 | Volume:7 | Issue:21 (SUPPLEMENTARY) Page(s): 35-41

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Title

THE EFFECT OF AQUEOUS EXTRACT OF MATRICARIA CHAMOMILLA ON THE ACQUISITION AND EXPRESSION OF MORPHINE INDUCED LOCOMOTOR SENSITIZATION IN ADULT MALE MICE

Author(s)

ASADZADE S. | Issue Writer Certificate

Keywords

MATRICARIA CHAMOMILLAQ2

AQUEOUS EXTRACTQ1

MORPHINEQ2

BEHAVIORAL SENSITIZATIONQ2

Abstract

The aim of this study was to evaluate of the effects of different doses of AQUEOUS EXTRACT of Matricaria Chamomillia on the acquisition and expression of MORPHINE-induced BEHAVIORAL SENSITIZATION in male N-MRI mice (20±5g). Locomotion was assessed by open field method. Sensitization was induced by single injection of MORPHINE (5mg/kg) in three consecutive days. Followed by 5 days resting on the 9th day of the experiments, the sensitization was assessed in animals by a single injection of very low dose of MORPHINE (0.5mg/kg). AQUEOUS EXTRACT (10, 20, 30 mg/kg) were administrated (i.p) during or after induction of MORPHINE sensitization, then the sensitization were tested in the animals. Results showed that administration of AQUEOUS EXTRACTs (10, 20, 30 mg/kg) 30 min before the MORPHINE administration caused hypoactivity. Administration of AQUEOUS EXTRACTs before MORPHINE injection in the training days, caused a significant decrease in locomotor activity in animals that reduced the acquisition of MORPHINE-induced BEHAVIORAL SENSITIZATION. Injection of AQUEOUS EXTRACT (20 mg/kg) in the test day, before MORPHINE administration also reduced the expression of MORPHINE induces BEHAVIORAL SENSITIZATION. It can be concluded that AQUEOUS EXTRACT of matricaria may inhibit locomotor activity in mice and also aqusition and expression of MORPHINE- induced BEHAVIORAL SENSITIZATION in male adult mice as well.

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References

THE STUDY OF LINDANE EFFECT ON PENTYLENETERTRAZOLE INDUCED CLONIZURE THRESHOLD IN MICE

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APA: Copy

ASADZADE, S.. (2011). THE EFFECT OF AQUEOUS EXTRACT OF MATRICARIA CHAMOMILLA ON THE ACQUISITION AND EXPRESSION OF MORPHINE INDUCED LOCOMOTOR SENSITIZATION IN ADULT MALE MICE. JOURNAL OF VETERINARY MICROBIOLOGY, 7(21 (SUPPLEMENTARY)), 35-41. SID. https://sid.ir/paper/152124/en

Vancouver: Copy

ASADZADE S.. THE EFFECT OF AQUEOUS EXTRACT OF MATRICARIA CHAMOMILLA ON THE ACQUISITION AND EXPRESSION OF MORPHINE INDUCED LOCOMOTOR SENSITIZATION IN ADULT MALE MICE. JOURNAL OF VETERINARY MICROBIOLOGY[Internet]. 2011;7(21 (SUPPLEMENTARY)):35-41. Available from: https://sid.ir/paper/152124/en

IEEE: Copy

S. ASADZADE, “THE EFFECT OF AQUEOUS EXTRACT OF MATRICARIA CHAMOMILLA ON THE ACQUISITION AND EXPRESSION OF MORPHINE INDUCED LOCOMOTOR SENSITIZATION IN ADULT MALE MICE,” JOURNAL OF VETERINARY MICROBIOLOGY, vol. 7, no. 21 (SUPPLEMENTARY), pp. 35–41, 2011, [Online]. Available: https://sid.ir/paper/152124/en

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