THE ROLE OF GABAA RECEPTORS IN MORPHINE-INDUCED LOCOMOTOR 
SENSITIZATION IN MICE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HEYDARI DARVISHANI A.; HAJIZADEH AKBAR; ZARINDAST M.R.; REZAYOF A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Advances in Cognitive Sciences Year:2007 | Volume:8 | Issue:4 (32) Page(s): 11-21

Download Full-Text

Persian Verion

View:

704

Download:

Cites:

Information Journal Paper

Title

THE ROLE OF GABAA RECEPTORS IN MORPHINE-INDUCED LOCOMOTOR SENSITIZATION IN MICE

Author(s)

Keywords

MURPHINE SULPHATEQ3

MUSCIMOLQ3

BICUCULLINEQ3

LOCOMOTOR ACTIVITYQ2

MOTOR SENSITIZATIONQ3

Abstract

Objective: This study was aimed to assess the effects of a GABAA receptor agonist (muscimol) and an antagonist (bicuculline) on morphine-induced locomtor sensitization in male mice.Method: 400 mice were cannulated by stereotaxy and made ready for injection. The program was performed in nine days and three stages. First, sensitization with medication was done in three days. Then for five deys mice did not receive any drugs, and finaly test was executed. LOCOMOTOR ACTIVITY of the animals was registered for a period of 20 minutes after words. The locomtor behavioral response of a morphine challenge dose (5 mg/kg, s.c.) given on day nine was enhanced in mice pretreated with morphine (7.5, 15 and 30 mg/kg/day). Data were analysed by analysis of variance and Tukey's post hoc.Results: subcutaneous injection of morphine (10, 20, 30, and 40, mg/kg) significantly increased the LOCOMOTOR ACTIVITY of the animals in a dose-dependent manner. Increase of LOCOMOTOR ACTIVITY in the mice with morphine pre-treatment (7.5, 15, and, 30 mg/kg) was a marker of sensitization. hree days administration of MUSCIMOL (0.025, 0.05,0.1, and 0.2 mg/mouse/day) significantly decreased morphine-induced motor stimulation (5mg/kg) both in the presence or absence of morphine. On the other hand 3-days pre-treatment with BICUCULLINE (0.25, 0.5, and 1 mg/mouse/day) with or without the prescence of morphine decreased the response of injection of MUSCIMOL (0.1 mg/mouse/day) to induction of LOCOMOTOR ACTIVITY by morphine (S mg/kg). Co-administration of BICUCULLINE (0.1, 0.2, and 0.5 mg/mouse) and MUSCIMOL (0.1 mg/mouse) significantly decreased the morphine- induced LOCOMOTOR ACTIVITY in the animals pre-treated with saline or morphine (15 mg/kg).Conclusion: The results indicate that GABAA receptors may be involved in development and expression of morphine –induced sensitization.

Cites

No record.

References

No record.

Cite

APA: Copy

HEYDARI DARVISHANI, A., HAJIZADEH, AKBAR, ZARINDAST, M.R., & REZAYOF, A.. (2007). THE ROLE OF GABA_A RECEPTORS IN MORPHINE-INDUCED LOCOMOTOR SENSITIZATION IN MICE. ADVANCES IN COGNITIVE SCIENCE, 8(4 (32)), 11-21. SID. https://sid.ir/paper/82836/en

Vancouver: Copy

HEYDARI DARVISHANI A., HAJIZADEH AKBAR, ZARINDAST M.R., REZAYOF A.. THE ROLE OF GABA_A RECEPTORS IN MORPHINE-INDUCED LOCOMOTOR SENSITIZATION IN MICE. ADVANCES IN COGNITIVE SCIENCE[Internet]. 2007;8(4 (32)):11-21. Available from: https://sid.ir/paper/82836/en

IEEE: Copy

A. HEYDARI DARVISHANI, AKBAR HAJIZADEH, M.R. ZARINDAST, and A. REZAYOF, “THE ROLE OF GABA_A RECEPTORS IN MORPHINE-INDUCED LOCOMOTOR SENSITIZATION IN MICE,” ADVANCES IN COGNITIVE SCIENCE, vol. 8, no. 4 (32), pp. 11–21, 2007, [Online]. Available: https://sid.ir/paper/82836/en

Related Journal Papers