Zn/La3⁺-Based MOFs: A Novel Approach for Controlled and Sustained Release of Captopril

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Malekzadeh Maryam; Yahyapour Moghadaseh

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF ANALYTICAL CHEMISTRY Year:2024 | Volume:11 | Issue:1 Page(s): 78-85

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Information Journal Paper

Title

Zn/La3⁺-Based MOFs: A Novel Approach for Controlled and Sustained Release of Captopril

Author(s)

Malekzadeh Maryam | Yahyapour Moghadaseh | Issue Writer Certificate

Keywords

Metal-organic frameworks

Drug release

Captopril

Abstract

This study presents the synthesis of Zn/La³⁺-based metal-organic frameworks (MOFs) using a co-precipitation assisted microwave method. Characterization through SEM and TEM revealed uniform nanoparticles around 80 nm. FT-IR spectroscopy confirmed the presence of key functional groups. Dynamic light scattering (DLS) showed highly uniform particle sizes. In vitro release studies of captopril from Zn/La³⁺/MOFs demonstrated a 41% release rate over 300 min, compared to 64% for pure captopril. Encapsulation within the MOF matrix ensured controlled and sustained drug release, with the first -order kinetic model fitting best. These Zn/La³⁺/MOFs show promise for enhanced and controlled drug delivery systems.

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