EVIDENCES FOR BALANCING SELECTION FROM PAH-BGLII AND PAH-ECORI POLYMORPHISMS IN ISFAHAN POPULATION

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FAZELI ATAR Z.; VALIAN BOROUJENI S.

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Journal: JOURNAL OF TAXONOMY AND BIOSISTEMATICS Year:2010 | Volume:1 | Issue:1 Page(s): 73-80

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Title

EVIDENCES FOR BALANCING SELECTION FROM PAH-BGLII AND PAH-ECORI POLYMORPHISMS IN ISFAHAN POPULATION

Author(s)

FAZELI ATAR Z. | VALIAN BOROUJENI S. | Issue Writer Certificate

Keywords

NEUTRALITY TESTQ4

ARLEQUIN PROGRAMQ4

DNA POLYMORPHISMQ4

PAH GENEQ4

Abstract

Two polymorphic markers including BglII and EcoRI, were identified at intron 1 and intron 5 of PAH GENE. In order to test whether these polymorphisms are behaving as neutral alleles or are being subjected to selective pressures in Isfahan population, 110 individuals were genotyped by PCR-RFLP. The Arlequin input file was prepared by use of phase-known haplotype data and NEUTRALITY TESTs (Tajima D test and Fu’s Fs test) were done using ARLEQUIN PROGRAM. 42 individuals were found heterozygous for both polymorphisms whose haplotype phase remained unknown. The BglII-EcoRI haplotype phase was known only at 68 individuals who were used for preparation of input file. Tajima's D value and Fs value at Isfahan population were 1.7 and 1.02, respectively. Positive values of Fs and D>0 indicated that these polymorphisms are under selection pressure at Isfahan population. Although these polymorphisms were in the non-coding region of PAH GENE, but these were not neutral alleles and positive values of these tests provided evidence for balancing selection of these polymorphisms at Isfahan population. The results of this study could improve our understanding of evolutionary history and structure of Isfahan population.

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APA: Copy

FAZELI ATAR, Z., & VALIAN BOROUJENI, S.. (2010). EVIDENCES FOR BALANCING SELECTION FROM PAH-BGLII AND PAH-ECORI POLYMORPHISMS IN ISFAHAN POPULATION. JOURNAL OF TAXONOMY AND BIOSISTEMATICS, 1(1), 73-80. SID. https://sid.ir/paper/160235/en

Vancouver: Copy

FAZELI ATAR Z., VALIAN BOROUJENI S.. EVIDENCES FOR BALANCING SELECTION FROM PAH-BGLII AND PAH-ECORI POLYMORPHISMS IN ISFAHAN POPULATION. JOURNAL OF TAXONOMY AND BIOSISTEMATICS[Internet]. 2010;1(1):73-80. Available from: https://sid.ir/paper/160235/en

IEEE: Copy

Z. FAZELI ATAR, and S. VALIAN BOROUJENI, “EVIDENCES FOR BALANCING SELECTION FROM PAH-BGLII AND PAH-ECORI POLYMORPHISMS IN ISFAHAN POPULATION,” JOURNAL OF TAXONOMY AND BIOSISTEMATICS, vol. 1, no. 1, pp. 73–80, 2010, [Online]. Available: https://sid.ir/paper/160235/en

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