ASSOCIATION OF APOA-I GENE POLYMORPHISMS AND LIPID PROFILE AND TYPE 2 DIABETES IN AN IRANIAN POPULATION

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BESHARATI A.; AKRAMI S.M.; HESHMAT RAMIN; YAGHMAEI PARICHEHR; ALI REZAPOUR B.

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Journal: Journal of Medical Council of Iran Year:2007 | Volume:25 | Issue:2 Page(s): 132-141

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Title

ASSOCIATION OF APOA-I GENE POLYMORPHISMS AND LIPID PROFILE AND TYPE 2 DIABETES IN AN IRANIAN POPULATION

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Keywords

DIABETESQ2

DYSLIPIDEMIAQ3

POLYMORPHISMQ2

APOA-IQ3

Abstract

Background: DYSLIPIDEMIA and type 2 DIABETES are common and complex metabolic diseases with strong genetic basis. There are many candidate genes for phenotypes that are related to these diseases. Studying the genetic factors related to these diseases is very important. APOA-I is the main protein composing HDL particle. The correlation between two POLYMORPHISMs of APOA-I gene (G-75A, C+83T) and HDL level have shown controversial results in various populations. This study was carried out to illustrate the role of these POLYMORPHISMs in an Iranian population. To the best of our knowledge, a similar study has not been done in an Iranian population so far. Methods: In a case-control study, a total of 215 volunteers were randomly selected from 17 districts of Tehran. DNA extraction was performed from their blood samples. Genotyping was done by Polymerase Chain Reaction (PCR) and then Restriction Fragment Length Polymerase (RFLP). Findings: There was not a significant relation between APOA-I gene promoter POLYMORPHISM and type 2 DIABETES. In the non-diabetic population with DYSLIPIDEMIA, we found a significant relation between AA POLYMORPHISM and increasing TG (P= 0.03). Also, there was a relation between GA POLYMORPHISM and increasing uric acid (P= 0.045). In the same POLYMORPHISM, GA/AA allele had a protective role for DYSLIPIDEMIA (P value= 0.028, OR=0.423, 95% CI=0.195-0.918). In C+83T POLYMORPHISM, the genotype CT was a risk for developing DIABETES (P Value = 0.028, OR=3.694, 95%CI=1.076-12.690). Conclusion: This study shows that APOA-I gene can be considered as an important goal for further etiologic studies in the field of metabolic disorders and DYSLIPIDEMIA.

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APA: Copy

BESHARATI, A., AKRAMI, S.M., HESHMAT, RAMIN, YAGHMAEI, PARICHEHR, & ALI REZAPOUR, B.. (2007). ASSOCIATION OF APOA-I GENE POLYMORPHISMS AND LIPID PROFILE AND TYPE 2 DIABETES IN AN IRANIAN POPULATION. JOURNAL OF MEDICAL COUNCIL OF I.R.I., 25(2), 132-141. SID. https://sid.ir/paper/41415/en

Vancouver: Copy

BESHARATI A., AKRAMI S.M., HESHMAT RAMIN, YAGHMAEI PARICHEHR, ALI REZAPOUR B.. ASSOCIATION OF APOA-I GENE POLYMORPHISMS AND LIPID PROFILE AND TYPE 2 DIABETES IN AN IRANIAN POPULATION. JOURNAL OF MEDICAL COUNCIL OF I.R.I.[Internet]. 2007;25(2):132-141. Available from: https://sid.ir/paper/41415/en

IEEE: Copy

A. BESHARATI, S.M. AKRAMI, RAMIN HESHMAT, PARICHEHR YAGHMAEI, and B. ALI REZAPOUR, “ASSOCIATION OF APOA-I GENE POLYMORPHISMS AND LIPID PROFILE AND TYPE 2 DIABETES IN AN IRANIAN POPULATION,” JOURNAL OF MEDICAL COUNCIL OF I.R.I., vol. 25, no. 2, pp. 132–141, 2007, [Online]. Available: https://sid.ir/paper/41415/en

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