POLY (E-CAPROLACTONE)/HYDROXYAPATITE SCAFFOLD: EVALUATION OF THE EFFECT OF THE AMOUNT OF HYDROXYAPATITE PARTICLES, COMPARE OF THE EFFECT OF NANOSCALE AND MICROSCALE PARTICLES AND THE EFFECT OF THEM ON MECHANICAL AND BIODEGRADABLE PROPERTIES OF BONE TISSUE ENGINEERING SCAFFOLD

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MOZAFFARI M.; JOHARI N.; FATHI M.H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: JOURNAL OF NEW MATERIALS Year:2015 | Volume:5 | Issue:4 (20) Page(s): 129-139

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Title

POLY (E-CAPROLACTONE)/HYDROXYAPATITE SCAFFOLD: EVALUATION OF THE EFFECT OF THE AMOUNT OF HYDROXYAPATITE PARTICLES, COMPARE OF THE EFFECT OF NANOSCALE AND MICROSCALE PARTICLES AND THE EFFECT OF THEM ON MECHANICAL AND BIODEGRADABLE PROPERTIES OF BONE TISSUE ENGINEERING SCAFFOLD

Author(s)

MOZAFFARI M. | JOHARI N. | FATHI M.H. | Issue Writer Certificate

Keywords

HYDROXYAPATITEQ2

POLY (S-CAPROLACTONE)Q1

COMPOSITE SCAFFOLDQ2

BIODEGRADATIONQ2

TISSUE ENGINEERINGQ2

Abstract

In this study, poly (s-caprolactone)/hydroxyapatit scaffold were produced by micro and nano HYDROXYAPATITE. Different weight fractions of 5, 10 and 15% of the HA were added to the PCL. PCL-HA scaffolds were prepared by solvent casting/particulate leaching method. Sodium chloride (NaCl) particle was used as a porogen with diameters 250-400 mm. Structural, chemical, mechanical and BIODEGRADATION properties of scaffolds were evaluated. The pore morphology, size, and distribution of the scaffolds were characterized using a scanning electron microscope (SEM). X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) were used to determine the phase structure, chemical composition and functional groups of scaffolds. Porosity of the scaffolds was measured using Archimedes' Principle according to a known method. These scaffolds were evaluated for their compressive mechanical properties. In vitro degradation was studied by immersing of scaffolds in phosphate buffered saline (PBS) up to 30 days. The changes of pH of the PBS and the changes of the weight loss of the scaffolds were measured. Results showed compressive strength and BIODEGRADATION of scaffolds increased with the increasing the weight ratio of HA. Also, the compressive strength of the scaffolds with nano HYDROXYAPATITE was greater than with micro HYDROXYAPATITE. But, BIODEGRADATION of the scaffolds with nano HYDROXYAPATITE was lesser than with micro HYDROXYAPATITE.

Cites

References

DESIGN AND SYNTHESIS OF BIODEGRADABLE NANO-GLASS COMPOSITE FOR USE IN TISSUE CULTURE ENGINEERING

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APA: Copy

MOZAFFARI, M., JOHARI, N., & FATHI, M.H.. (2015). POLY (E-CAPROLACTONE)/HYDROXYAPATITE SCAFFOLD: EVALUATION OF THE EFFECT OF THE AMOUNT OF HYDROXYAPATITE PARTICLES, COMPARE OF THE EFFECT OF NANOSCALE AND MICROSCALE PARTICLES AND THE EFFECT OF THEM ON MECHANICAL AND BIODEGRADABLE PROPERTIES OF BONE TISSUE ENGINEERING SCAFFOLD. JOURNAL OF NEW MATERIALS, 5(4 (20)), 129-139. SID. https://sid.ir/paper/170012/en

Vancouver: Copy

MOZAFFARI M., JOHARI N., FATHI M.H.. POLY (E-CAPROLACTONE)/HYDROXYAPATITE SCAFFOLD: EVALUATION OF THE EFFECT OF THE AMOUNT OF HYDROXYAPATITE PARTICLES, COMPARE OF THE EFFECT OF NANOSCALE AND MICROSCALE PARTICLES AND THE EFFECT OF THEM ON MECHANICAL AND BIODEGRADABLE PROPERTIES OF BONE TISSUE ENGINEERING SCAFFOLD. JOURNAL OF NEW MATERIALS[Internet]. 2015;5(4 (20)):129-139. Available from: https://sid.ir/paper/170012/en

IEEE: Copy

M. MOZAFFARI, N. JOHARI, and M.H. FATHI, “POLY (E-CAPROLACTONE)/HYDROXYAPATITE SCAFFOLD: EVALUATION OF THE EFFECT OF THE AMOUNT OF HYDROXYAPATITE PARTICLES, COMPARE OF THE EFFECT OF NANOSCALE AND MICROSCALE PARTICLES AND THE EFFECT OF THEM ON MECHANICAL AND BIODEGRADABLE PROPERTIES OF BONE TISSUE ENGINEERING SCAFFOLD,” JOURNAL OF NEW MATERIALS, vol. 5, no. 4 (20), pp. 129–139, 2015, [Online]. Available: https://sid.ir/paper/170012/en

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