BIOCHEMICAL AND HISTOPATHOLOGICAL STUDY OF THE TOXICITY OF ZINC OXIDE NANOPARTICLES ON LIVER IN RAT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HOSSEINI S.M.; MOSHREFI A.H.; AMANI R.; RAZAVIMEHR S.V.; AGHAJANIKHAH M.H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ANIMAL BIOLOGY Year:2016 | Volume:8 | Issue:4 Page(s): 37-47

Download Full-Text

Persian Verion

View:

893

Download:

Cites:

Information Journal Paper

Title

BIOCHEMICAL AND HISTOPATHOLOGICAL STUDY OF THE TOXICITY OF ZINC OXIDE NANOPARTICLES ON LIVER IN RAT

Author(s)

Keywords

NANOPARTICLEQ1

LIVERQ2

ZINC OXIDEQ1

TOXICITYQ1

LIVER ENZYMESQ2

Abstract

Zinc oxide (ZnO) is one of the most widely used materials in diverse industrial fields, for this reason most widely produced and Have many technological applications. The human body may be intentionally or unintentionally exposed to these NANOPARTICLEs. In this study, acute TOXICITY of ZINC OXIDE NANOPARTICLEs on the LIVER enzymes and LIVER histopathology was evaluated. Fifty female rats with 180-220 grams of weight were divided into five groups, including control, Sham and Three groups with different doses of ZnO NANOPARTICLE (25, 50 and 100 mg/kg twice a week for four weeks). The rats were then sacrificed and cholesterol, triglycerides, total protein, albumin and LIVER enzymes (ALT, AST and ALP) were determined and LIVERs were fixed in formalin processed, sectioned and stained with Hematoxylin- Eosin.After removal of the tissue, samples digestion and zinc concentrations were measured by atomic absorption; Finally Data were analyzed using one way ANOVA. Also the most of the Zno NANOPARTICLEs absorption on the dose of 100 mg/kg was observed. Histopathological analysis of LIVER sections showed tissue damage, such as necrosis, congestion and vacuolar degeneration at a dose of 25 mg/ kg and in addition inflammatory cell infiltration in doses 50 and 100 mg/kg was observed. In Serological study also increased serum ALT, AST and ALP LIVER enzymes levels. Results of the present study showed the dose-dependent TOXICITY of ZnO NANOPARTICLEs on the LIVER; therefore exposure to NANOPARTICLEs can make serious risks in humans.

Cites

No record.

References

No record.

Cite

APA: Copy

HOSSEINI, S.M., MOSHREFI, A.H., AMANI, R., RAZAVIMEHR, S.V., & AGHAJANIKHAH, M.H.. (2016). BIOCHEMICAL AND HISTOPATHOLOGICAL STUDY OF THE TOXICITY OF ZINC OXIDE NANOPARTICLES ON LIVER IN RAT. JOURNAL OF ANIMAL BIOLOGY, 8(4), 37-47. SID. https://sid.ir/paper/176765/en

Vancouver: Copy

HOSSEINI S.M., MOSHREFI A.H., AMANI R., RAZAVIMEHR S.V., AGHAJANIKHAH M.H.. BIOCHEMICAL AND HISTOPATHOLOGICAL STUDY OF THE TOXICITY OF ZINC OXIDE NANOPARTICLES ON LIVER IN RAT. JOURNAL OF ANIMAL BIOLOGY[Internet]. 2016;8(4):37-47. Available from: https://sid.ir/paper/176765/en

IEEE: Copy

S.M. HOSSEINI, A.H. MOSHREFI, R. AMANI, S.V. RAZAVIMEHR, and M.H. AGHAJANIKHAH, “BIOCHEMICAL AND HISTOPATHOLOGICAL STUDY OF THE TOXICITY OF ZINC OXIDE NANOPARTICLES ON LIVER IN RAT,” JOURNAL OF ANIMAL BIOLOGY, vol. 8, no. 4, pp. 37–47, 2016, [Online]. Available: https://sid.ir/paper/176765/en

Related Journal Papers