THE EFFECTS OF HYDROALCOHOLIC EXTRACT OF SALVIA OFFICINALIS ON LIVER TISSUE AND CU, FE, ZN AND MG ELEMENTS IN MALE RATS

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KHAKPOUR SH.; KHOSRAVI M.; MIRZAIE M.; NAJARI M.

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Journal: JOURNAL OF ANIMAL BIOLOGY Year:2014 | Volume:6 | Issue:2 Page(s): 29-40

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Title

THE EFFECTS OF HYDROALCOHOLIC EXTRACT OF SALVIA OFFICINALIS ON LIVER TISSUE AND CU, FE, ZN AND MG ELEMENTS IN MALE RATS

Author(s)

KHAKPOUR SH. | KHOSRAVI M. | MIRZAIE M. | NAJARI M. | Issue Writer Certificate

Keywords

OXIDATIVE STRESSQ1

FREE RADICALQ2

ANTIOXIDANTQ1

SALVIA OFFICINALISQ2

ISONIAZIDQ2

Abstract

The imbalance between the production of FREE RADICALs and ANTIOXIDANT can be the cause of OXIDATIVE STRESS. OXIDATIVE STRESS induces different diseases and tissue damages. ISONIAZID has been used for the purpose of producing FREE RADICALs. In the present study, we investigated the effects of SALVIA OFFICINALIS hydroalcoholic extract on blood elements such as Fe, Mg, Zn and Cu. In this study, 63 male rats were used and divided in 9 groups; in each group 7 rats were included. ISONIAZID 50mg/kg was orally administered to rats continuously once per day for 28 days using a feeding atraumatic needle. The experimental groups received for 28 days, SALVIA OFFICINALIS hydroalcoholic extract with the doses 100, 250 and 400 mg/kg intraperitoneally, and also some experimental groups were coadministered with different doses of the extract and ISONIAZID; the results of serum Fe, Mg, Zn and Cu were compared with the control and sham groups, as well. Also, the animal livers of all groups were separated and dissected for the histopathological studies. Zn and Cu were increased significantly in the treated-groups with SALVIA OFFICINALIS, but the levels of Fe and Mg showed a significant decrease in the experimental groups treated with all the doses of SALVIA OFFICINALIS hydroalcoholic extract. It seems that tannin and bitter compounds of SALVIA OFFICINALIS hydroalcoholic extract are the main agents to alternate the blood element levels.

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APA: Copy

KHAKPOUR, SH., KHOSRAVI, M., MIRZAIE, M., & NAJARI, M.. (2014). THE EFFECTS OF HYDROALCOHOLIC EXTRACT OF SALVIA OFFICINALIS ON LIVER TISSUE AND CU, FE, ZN AND MG ELEMENTS IN MALE RATS. JOURNAL OF ANIMAL BIOLOGY, 6(2), 29-40. SID. https://sid.ir/paper/176853/en

Vancouver: Copy

KHAKPOUR SH., KHOSRAVI M., MIRZAIE M., NAJARI M.. THE EFFECTS OF HYDROALCOHOLIC EXTRACT OF SALVIA OFFICINALIS ON LIVER TISSUE AND CU, FE, ZN AND MG ELEMENTS IN MALE RATS. JOURNAL OF ANIMAL BIOLOGY[Internet]. 2014;6(2):29-40. Available from: https://sid.ir/paper/176853/en

IEEE: Copy

SH. KHAKPOUR, M. KHOSRAVI, M. MIRZAIE, and M. NAJARI, “THE EFFECTS OF HYDROALCOHOLIC EXTRACT OF SALVIA OFFICINALIS ON LIVER TISSUE AND CU, FE, ZN AND MG ELEMENTS IN MALE RATS,” JOURNAL OF ANIMAL BIOLOGY, vol. 6, no. 2, pp. 29–40, 2014, [Online]. Available: https://sid.ir/paper/176853/en

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