The Effect of Coenzyme Q10 on the Nervous Protection and Movement Disorders in Model of Mice Parkinson’ s Disease induced by 6-HDOP

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AZARSHAB M.; SOLATI J.; Hahikhani R.; RAHNEMA M.; BIGDELI M.R.

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Journal: JOURNAL OF ANIMAL BIOLOGY Year:2019 | Volume:11 | Issue:2 Page(s): 1-12

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Title

The Effect of Coenzyme Q10 on the Nervous Protection and Movement Disorders in Model of Mice Parkinson’ s Disease induced by 6-HDOP

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Keywords

MiceQ2

6-HydroxydopamineQ1

Substantia NigraQ1

ParkinsonQ1

Coenzyme Q10Q1

Abstract

Parkinson’ s disease is one of the most common types of neurodegenerative diseases characterized by motor disorders such as slow motion, lack of movement, muscle stiffness, resting vibrations and facial masks. The main cause of the disease is the destruction of dopaminergic neurons in the compact part of the Substantia Nigra in the middle cerebrum, which is associated with a decrease in dopamine concentration at the terminals of corpus striatum. This study was conducted to investigate the effect of Coenzyme Q10 on the 6-Hydroxydopamine-induced animal model (PD). To create a mock-up model of Parkinson’ s disease, 6-HDOP poison five μ g/kg of Mice body weight was injected into the Substantia Nigra nucleus in adult NMRI Mice. The accuracy of the Parkinson’ s model in Mice was confirmed using catalepsy and apomorphine-induced rotation tests. Immediately after surgery, the Parkinsonian Mice were treated with water (solvent Q10) at doses of 25, 50, and 100 Coenzyme Q10 for two weeks and then subjected to behavioural tests, and the neurons of the Substantia Nigra nucleus were counted. The results indicated that treatment with Q10 significantly reduced the immobility time and Catalepsy, increased motor activity and decreased apomorphine rotation, indicating the protective effects of Coenzyme Q10 against Parkinson’ s disease damage.

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APA: Copy

AZARSHAB, M., SOLATI, J., Hahikhani, R., RAHNEMA, M., & BIGDELI, M.R.. (2019). The Effect of Coenzyme Q10 on the Nervous Protection and Movement Disorders in Model of Mice Parkinson’ s Disease induced by 6-HDOP. JOURNAL OF ANIMAL BIOLOGY, 11(2 ), 1-12. SID. https://sid.ir/paper/176883/en

Vancouver: Copy

AZARSHAB M., SOLATI J., Hahikhani R., RAHNEMA M., BIGDELI M.R.. The Effect of Coenzyme Q10 on the Nervous Protection and Movement Disorders in Model of Mice Parkinson’ s Disease induced by 6-HDOP. JOURNAL OF ANIMAL BIOLOGY[Internet]. 2019;11(2 ):1-12. Available from: https://sid.ir/paper/176883/en

IEEE: Copy

M. AZARSHAB, J. SOLATI, R. Hahikhani, M. RAHNEMA, and M.R. BIGDELI, “The Effect of Coenzyme Q10 on the Nervous Protection and Movement Disorders in Model of Mice Parkinson’ s Disease induced by 6-HDOP,” JOURNAL OF ANIMAL BIOLOGY, vol. 11, no. 2 , pp. 1–12, 2019, [Online]. Available: https://sid.ir/paper/176883/en

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