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Information Journal Paper

Title

Evaluation of the Effects of QlO on Neural Protection and Behavioral Disorders in Cell Culture and Mice Models of Parkinson's Disease

Pages

  75-93

Abstract

 Inroduction & Objective: Oxidative stress which is responsible for pathophysiology of Hypertension, causes decrease in total antioxidant capacity. PON 1 is an antioxidant enzyme present on the surface of HDL also which is responsible for prevention of HTN and it's complications. The aim of this study was to investigate the Effect of Isosorbide and Garlic Supplementation on Protein levels and Gene expression of PONl at the Heart tissue in Female rats with Hypertension After a period of aerobic training. Materials and Methods: In the experimental study, 30 female Wistar rats weighing 180-220 g were randomly divided into 8 groups: healthy control, sham, blood pressure induction (Hyper), Garlic, endurance training, endurance training-Garlic. The rats suffered from Hypertension of 6 days a week for 8 weeks after dietary period and 10 mg/kg body weight L_NAME injection. Experimental groups received 50 mg/kg body weight Garlic supplement for six weeks. The endurance training program was performed at speeds of 20-30 m/min and 20 to 35 minutes, 5 sessions per week for 6 weeks. Protein levels and expression of PONl heart tissue were measured using ELISA kit and Real Time PCR. Data were analyzed by t-test, One-way ANOV A and post hoc tokey at the significant level P<0. 05. Results: The results showed that there was no significant difference between the mean protein and the expression of paraoxonase-1 in the heart tissue of the Female rats with Hypertension in the different groups of the study (P> 0. 05). Also, there was no difference between the levels of protein paraoxonase-1 heart tissue in different groups than the group of blood pressure induction (P> 0. 05). Conclusion: According to the findings, it seems to that the inadequacy of the training period (frequency and intensity of Exercise) and the dose rate of Garlic Supplementation can be one of the possible causes of ineffectiveness in the present study.

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    APA: Copy

    Aazarshab, M., RAHNEMA, M., HAJIKHANI, R., SOLATI, J., & BIGDELI, M.R.. (2019). Evaluation of the Effects of QlO on Neural Protection and Behavioral Disorders in Cell Culture and Mice Models of Parkinson's Disease. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), 12(4 (47) ), 75-93. SID. https://sid.ir/paper/402795/en

    Vancouver: Copy

    Aazarshab M., RAHNEMA M., HAJIKHANI R., SOLATI J., BIGDELI M.R.. Evaluation of the Effects of QlO on Neural Protection and Behavioral Disorders in Cell Culture and Mice Models of Parkinson's Disease. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES)[Internet]. 2019;12(4 (47) ):75-93. Available from: https://sid.ir/paper/402795/en

    IEEE: Copy

    M. Aazarshab, M. RAHNEMA, R. HAJIKHANI, J. SOLATI, and M.R. BIGDELI, “Evaluation of the Effects of QlO on Neural Protection and Behavioral Disorders in Cell Culture and Mice Models of Parkinson's Disease,” JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), vol. 12, no. 4 (47) , pp. 75–93, 2019, [Online]. Available: https://sid.ir/paper/402795/en

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