THE INFLUENCE OF L-ARGININE IN THE IMPROVING EFFECT OF NICOTINE ON ETHANOL-INDUCED AMNESIA

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PIRI M.; MOSHFEGH A.; RAOUFI N.; SHAHIN M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: JOURNAL OF ANIMAL BIOLOGY Year:2012 | Volume:4 | Issue:2 Page(s): 23-32

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Title

THE INFLUENCE OF L-ARGININE IN THE IMPROVING EFFECT OF NICOTINE ON ETHANOL-INDUCED AMNESIA

Author(s)

PIRI M. | MOSHFEGH A. | RAOUFI N. | SHAHIN M. | Issue Writer Certificate

Keywords

DORSAL HIPPOCAMPUSQ2

ETHANOL INDUCED AMNESIAQ2

NICOTINEQ2

NITRIC OXIDE PRECURSORQ2

Abstract

Nitric oxide synthase has been detected in DORSAL HIPPOCAMPUS, which is a key brain region that seems mediate behavioral effect of ethanol and NICOTINE. In the present study, the effects of L-arginine, a NITRIC OXIDE PRECURSOR, in the DORSAL HIPPOCAMPUS in NICOTINE’s effect on ethanol-induced amnesia was investigated. This experimental study was performed on 300 male mice. Mice were anesthetized with intra-peritoneal injection of ketamine hydrochloride, plus xylazine and then placed in a stereotaxic apparatus. The animals were bilaterally implanted with chronic cannulae in the CA1 regions of the DORSAL HIPPOCAMPUS, trained in a step-down type inhibitory avoidance task, and tested 24 h after training to measure step-down latency. Pre-training or pre-test injection of ethanol (1 g/kg) decreased the memory retrieval. Injection of NICOTINE or L-arginine before test by itself has no effect on memory retrieval. On the other hand, pre-test administration of ethanol (0.5, 1 g/kg), NICOTINE (0.4, 0.8 µg/mice) or L-arginine (0.8 µg/mice) plus non-effective dose of NICOTINE (0.2 µg/mice) restored memory impairment induced by pre-training injection of ethanol. These results suggest that nitric oxide system of DORSAL HIPPOCAMPUS may play an important role in the improving effect of NICOTINE on the ethanol-induced amnesia.

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APA: Copy

PIRI, M., MOSHFEGH, A., RAOUFI, N., & SHAHIN, M.. (2012). THE INFLUENCE OF L-ARGININE IN THE IMPROVING EFFECT OF NICOTINE ON ETHANOL-INDUCED AMNESIA. JOURNAL OF ANIMAL BIOLOGY, 4(2), 23-32. SID. https://sid.ir/paper/176919/en

Vancouver: Copy

PIRI M., MOSHFEGH A., RAOUFI N., SHAHIN M.. THE INFLUENCE OF L-ARGININE IN THE IMPROVING EFFECT OF NICOTINE ON ETHANOL-INDUCED AMNESIA. JOURNAL OF ANIMAL BIOLOGY[Internet]. 2012;4(2):23-32. Available from: https://sid.ir/paper/176919/en

IEEE: Copy

M. PIRI, A. MOSHFEGH, N. RAOUFI, and M. SHAHIN, “THE INFLUENCE OF L-ARGININE IN THE IMPROVING EFFECT OF NICOTINE ON ETHANOL-INDUCED AMNESIA,” JOURNAL OF ANIMAL BIOLOGY, vol. 4, no. 2, pp. 23–32, 2012, [Online]. Available: https://sid.ir/paper/176919/en

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