DESIGN, FABRICATION AND PERFORMANCE OF DEP-SAW SENSOR FOR AGGREGATION MEASUREMENT OF CELLS ON A LAB ON CHIP

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GHAYOUR REZA; HOJJAT YOUSEF

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Journal: Modares Mechanical Engineering Year:2018 | Volume:18 | Issue:2 Page(s): 351-358

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Title

DESIGN, FABRICATION AND PERFORMANCE OF DEP-SAW SENSOR FOR AGGREGATION MEASUREMENT OF CELLS ON A LAB ON CHIP

Author(s)

GHAYOUR REZA | HOJJAT YOUSEF | Issue Writer Certificate

Keywords

SAWQ1

DIELECTROPHORESISQ1

CELLQ1

NANOWIREQ1

Abstract

In surface acoustic wave sensors, target CELLs are trapped by sacrificial layer, containing antigens and antibodies. In this new idea, sacrificial layer is replaced by diectrophoresis electrodes. Fast response and not being disposable and usability for various types of CELLs are its advantages. In order to design and fabricate the sensor, the optimized values of effective parameters have been investigated. The behavior Love wave - which is used in this sensor - is simulated with lithium Niobate as substrate and ZnO layer as guiding layer. Two types of focus and unfocused interdigital transducer electrodes for sensor are investigated. The results of the sensitivity analysis and its relationship with the sensor displacement are presented. In graphs, results indicate that the focused circular structure is more sensitive, when the number of target CELLs in the fluid channel is more. The sensor was tested in 142 MHz for healthy and cancerous brain and intestinal CELLs. The suggested sensor has good results for measurement of CELLs aggregation. Wave power loss in transmission from sender to receiver ports and frequency shift are two special properties for detecting healthy and cancerous CELLs. Results show 80 and 90 KHz decrease in frequency and 4.99 and 6.69 dB loss decrease in cancerous CELLs comparing to healthy CELLs in brain and intestinal CELLs respectively. In this sensor, trapping, detecting and measurement of aggregation, happens in 5-10 second, which is an outstanding result compare to 10-15 minutes in conventional methods.

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APA: Copy

GHAYOUR, REZA, & HOJJAT, YOUSEF. (2018). DESIGN, FABRICATION AND PERFORMANCE OF DEP-SAW SENSOR FOR AGGREGATION MEASUREMENT OF CELLS ON A LAB ON CHIP. MODARES MECHANICAL ENGINEERING, 18(2 ), 351-358. SID. https://sid.ir/paper/178653/en

Vancouver: Copy

GHAYOUR REZA, HOJJAT YOUSEF. DESIGN, FABRICATION AND PERFORMANCE OF DEP-SAW SENSOR FOR AGGREGATION MEASUREMENT OF CELLS ON A LAB ON CHIP. MODARES MECHANICAL ENGINEERING[Internet]. 2018;18(2 ):351-358. Available from: https://sid.ir/paper/178653/en

IEEE: Copy

REZA GHAYOUR, and YOUSEF HOJJAT, “DESIGN, FABRICATION AND PERFORMANCE OF DEP-SAW SENSOR FOR AGGREGATION MEASUREMENT OF CELLS ON A LAB ON CHIP,” MODARES MECHANICAL ENGINEERING, vol. 18, no. 2 , pp. 351–358, 2018, [Online]. Available: https://sid.ir/paper/178653/en

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