The Effect of the Surfactant PS-PVP in the Preparation of Alumina Nanoparticles and its Investigation as a Nanomaterial in Curcumin Delivery

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Alem Masoumeh; TARLANI ALIAKBAR; AGHABOZORG HAMID REZA; KHOSRAVI MORTEZA

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Journal: Journal of Applied Research in Chemistry Year:2019 | Volume:13 | Issue:1 Page(s): 49-59

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Title

The Effect of the Surfactant PS-PVP in the Preparation of Alumina Nanoparticles and its Investigation as a Nanomaterial in Curcumin Delivery

Author(s)

Alem Masoumeh | TARLANI ALIAKBAR | AGHABOZORG HAMID REZA | KHOSRAVI MORTEZA | Issue Writer Certificate

Keywords

CurcuminQ1

Mesoporous AluminaQ1

SurfactantQ1

PVP-PSQ1

Abstract

In this research, a series of Mesoporous Alumina (MA) nanostructured materials was synthesized by an evaporation-induced self-assembly using the mixture of nonionic Surfactant PS-PVP and cationic Surfactant CTAB in acidic and basic conditions. The aluminum source was aluminum-tri-sec-butoxide. The effects of Surfactant type, pH and calcination temperature on the physical properties of the resulting MAs were investigated. The samples were characterized by N2 adsorption– desorption isotherms, X-ray diffraction (XRD) and scanning electron microscope (SEM). The results showed that the synthesized sample using mixture Surfactants have high surface area and high pore volume in basic condition at 550 oC. Poorly soluble Curcumin was selected as model drug to evaluate the release behavior from Mesoporous Alumina. Curcumin was loaded on MAs by the impregnation method. The in vitro release behavior of these compounds was studied in simulated gastric fluid (SGF, pH = 1. 2) and simulated intestinal fluid (SIF, pH = 6. 8). The release of insoluble Curcumin was 90% within 12 h. Kinetics of released Curcumin followed from Korsmeyer-Peppas model at the both of simulated fluids.

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APA: Copy

Alem, Masoumeh, TARLANI, ALIAKBAR, AGHABOZORG, HAMID REZA, & KHOSRAVI, MORTEZA. (2019). The Effect of the Surfactant PS-PVP in the Preparation of Alumina Nanoparticles and its Investigation as a Nanomaterial in Curcumin Delivery. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), 13(1 ), 49-59. SID. https://sid.ir/paper/180134/en

Vancouver: Copy

Alem Masoumeh, TARLANI ALIAKBAR, AGHABOZORG HAMID REZA, KHOSRAVI MORTEZA. The Effect of the Surfactant PS-PVP in the Preparation of Alumina Nanoparticles and its Investigation as a Nanomaterial in Curcumin Delivery. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)[Internet]. 2019;13(1 ):49-59. Available from: https://sid.ir/paper/180134/en

IEEE: Copy

Masoumeh Alem, ALIAKBAR TARLANI, HAMID REZA AGHABOZORG, and MORTEZA KHOSRAVI, “The Effect of the Surfactant PS-PVP in the Preparation of Alumina Nanoparticles and its Investigation as a Nanomaterial in Curcumin Delivery,” JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), vol. 13, no. 1 , pp. 49–59, 2019, [Online]. Available: https://sid.ir/paper/180134/en

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