Preparation of fluorinated hydroxyapatite nanoparticles and study the possibility of its application to ibuprofen drug delivery

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Naghashi Azita; TORKIAN LEILA; MOTAKEF KAZEMI NEGAR

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Journal: Journal of Applied Research in Chemistry Year:2019 | Volume:13 | Issue:3 Page(s): 41-50

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Information Journal Paper

Title

Preparation of fluorinated hydroxyapatite nanoparticles and study the possibility of its application to ibuprofen drug delivery

Author(s)

Naghashi Azita | TORKIAN LEILA | MOTAKEF KAZEMI NEGAR | Issue Writer Certificate

Keywords

HydroxyapatiteQ2

NanoparticlesQ1

Drug deliveryQ2

IbuprofenQ1

Abstract

In this paper, Hydroxyapatite Nanoparticles were synthesized and substituted by fluorine atoms. Then the prepared Nanoparticles were applied for loading and releasing of Ibuprofen as a drug model in a body stimulated system. At last, toxicity of Nanoparticles was investigated through MTT studies. In order to study the morphology and characterizing the structures of Nanoparticles Scanning Electron Microscopy and FT-IR spectroscopy were applied. Drug loading and releasing processes were investigated via TGA and UV-Visible instruments. Higher amounts of fluorine resulted in increasing crystallite sizes from 35 to 53 nm and particle sizes from 50 to 77 nm. It also enriches the drug loading and releasing amounts. HAP and FHAP are not toxic but show light toxicity by fluorine amount increasing. Ibuprofen is utilizable for loading and releasing from HAP and FHAP in body only by 25 percent concentration.

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APA: Copy

Naghashi, Azita, TORKIAN, LEILA, & MOTAKEF KAZEMI, NEGAR. (2019). Preparation of fluorinated hydroxyapatite nanoparticles and study the possibility of its application to ibuprofen drug delivery. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), 13(3 ), 41-50. SID. https://sid.ir/paper/180305/en

Vancouver: Copy

Naghashi Azita, TORKIAN LEILA, MOTAKEF KAZEMI NEGAR. Preparation of fluorinated hydroxyapatite nanoparticles and study the possibility of its application to ibuprofen drug delivery. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)[Internet]. 2019;13(3 ):41-50. Available from: https://sid.ir/paper/180305/en

IEEE: Copy

Azita Naghashi, LEILA TORKIAN, and NEGAR MOTAKEF KAZEMI, “Preparation of fluorinated hydroxyapatite nanoparticles and study the possibility of its application to ibuprofen drug delivery,” JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), vol. 13, no. 3 , pp. 41–50, 2019, [Online]. Available: https://sid.ir/paper/180305/en

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