PROTECTIVE EFFECTS OF RESVERATROL AGAINST CHEMOTHERAPY DRUG CISPLATIN INDUCED HEPATOTOXICITY IN THE RAT

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KAFFASHI ELAHI R.

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Journal: VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ) Year:2014 | Volume:7 | Issue:4 (28) Page(s): 286-299

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Title

PROTECTIVE EFFECTS OF RESVERATROL AGAINST CHEMOTHERAPY DRUG CISPLATIN INDUCED HEPATOTOXICITY IN THE RAT

Author(s)

KAFFASHI ELAHI R. | Issue Writer Certificate

Keywords

RESVERATROLQ2

CISPLATINQ2

HEPATOTOXICITYQ2

RATQ2

Abstract

Drug therapy of cancer which is carried out by natural, synthetic or biological substances is associated with complications. CISPLATIN as an anticancer drug, is hepatotoxic at high doses. Oxidative stress has been proven to be involved in CISPLATIN-induced toxicity. Because of antioxidant potential of RESVERATROL, this study was conducted to assess the protective effects of RESVERATROL, on CISPLATIN-induced HEPATOTOXICITY in the RAT. Forty male Wistar RATs were randomly divided into four equal groups. Group 1 was used as control. For induction of hepatic injury in groups 2-4, CISPLATIN (3 mg/kg) was injected once every five days intraperitoneally. Groups 3 and 4 received silymarin (100 mg/kg) and RESVERATROL (20 mg/kg) respectively, daily for 4 weeks via intraperitoneal route. At the end of experiment, serum levels of aspartate and alanine transaminases, lactate dehydogenase and total bilirubin, albumin and total proteins were assessed. Malondialdehyde, reduced glutathione and activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase were assayed in liver homogenates. Finally, the biochemical findings were matched with histopathological verification. In group 4, RESVERATROL significantly (p<0.001) decreased the elevated levels of serum biomarkers of hepatic injury and total bilirubin, and significantly (p<0.001) increased the reduced levels of serum albumin and total proteins. In this group, RESVERATROL significantly (p<0.001) decreased the lipid peroxidation and elevated the decreased values of hepatic antioxidants. Histopathologically, the changes were in agreement with biochemical findings. The results obtained showed RESVERATROL, because of its anti-oxidant potential, exerts a protective effect against CISPLATIN induced HEPATOTOXICITY in RATs.

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APA: Copy

KAFFASHI ELAHI, R.. (2014). PROTECTIVE EFFECTS OF RESVERATROL AGAINST CHEMOTHERAPY DRUG CISPLATIN INDUCED HEPATOTOXICITY IN THE RAT. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), 7(4 (28)), 286-299. SID. https://sid.ir/paper/183246/en

Vancouver: Copy

KAFFASHI ELAHI R.. PROTECTIVE EFFECTS OF RESVERATROL AGAINST CHEMOTHERAPY DRUG CISPLATIN INDUCED HEPATOTOXICITY IN THE RAT. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ)[Internet]. 2014;7(4 (28)):286-299. Available from: https://sid.ir/paper/183246/en

IEEE: Copy

R. KAFFASHI ELAHI, “PROTECTIVE EFFECTS OF RESVERATROL AGAINST CHEMOTHERAPY DRUG CISPLATIN INDUCED HEPATOTOXICITY IN THE RAT,” VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), vol. 7, no. 4 (28), pp. 286–299, 2014, [Online]. Available: https://sid.ir/paper/183246/en

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