THE EFFECTS OF PRETREATMENT WITH VARIOUS DOSES OF L-ARGININE ON CISPLATIN-INDUCED NEPHROPATHY OF MALE RATS

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RASOULIAN BAHRAM; MoradiRad Nassim; JABARI MAHBOUBEH; RASHIDIPOUR MARZIEH; KHOSHDEL ZEYNAB; ALIREZAEI MASOUD; BEHRAHI FARNAZ

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2016 | Volume:24 | Issue:6 Page(s): 491-500

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Title

THE EFFECTS OF PRETREATMENT WITH VARIOUS DOSES OF L-ARGININE ON CISPLATIN-INDUCED NEPHROPATHY OF MALE RATS

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LQ2

ARGININEQ2

CISPLATINQ2

NEPHROTOXICITYQ2

NEPHROPATHYQ2

Abstract

Introduction: CISPLATIN is a widely used anti-cancer drug, which its application is limited by NEPHROTOXICITY. In this study, the effect of pretreatment with different l-arginine doses on CISPLATIN-induced renal functional injury was investigated.Methods: 63 male rats were divided into 7 groups: In groups 3, 4, 5 and 6, 60 min before the CISPLATIN injection (5mg/kg); L-Arginine with doses of 50,100, 200 or 400mg/kg was injected, respectively. In group7, normal saline was injected before CISPLATIN administration. In groups 1 and 2, normal saline was injected instead of CISPLATIN. In group 2, 60min before normal saline injection, 400mg/kg L-Arginine was administered and in group1, instead of L-arginine, normal saline was injected too. Injections were intraperitoneal. 72h after CISPLATIN injection, blood sampling and plasma separation were done. Urine sample was collected 24 hours before blood sampling by metabolic cage. The mean of plasma urea and creatinine levels and creatinine clearance (ml/day.kg) and fractional excretion of Na (FENa, %) were compared among different groups as renal functional parameters.Results: In comparison to group 7, L-arginine injection in a dose of 400mg/kg led to significant amelioration of all parameters. 200 mg/kg L-arginine administration led to significant decrease in plasma urea level and FENa. 100mg/kg L-arginine caused significant improvement in fractional excretion of sodium. L-arginine injection with 50 mg/kg dose, significantly ameliorate all renal function tests instead of creatinine clearance.Conclusion: Pretreatment with L-arginine administration with 400 or 50 mg/kg doses, respectively, had the highest effect on reducing CISPLATIN-induced NEPHROPATHY. L-arginine injection with intermediate doses i.e. 200 or 100 mg/kg had less effect in reducing CISPLATIN-induced NEPHROPATHY and it needs more investigations.

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APA: Copy

RASOULIAN, BAHRAM, MoradiRad, Nassim, JABARI, MAHBOUBEH, RASHIDIPOUR, MARZIEH, KHOSHDEL, ZEYNAB, ALIREZAEI, MASOUD, & BEHRAHI, FARNAZ. (2016). THE EFFECTS OF PRETREATMENT WITH VARIOUS DOSES OF L-ARGININE ON CISPLATIN-INDUCED NEPHROPATHY OF MALE RATS. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 24(6), 491-500. SID. https://sid.ir/paper/36182/en

Vancouver: Copy

RASOULIAN BAHRAM, MoradiRad Nassim, JABARI MAHBOUBEH, RASHIDIPOUR MARZIEH, KHOSHDEL ZEYNAB, ALIREZAEI MASOUD, BEHRAHI FARNAZ. THE EFFECTS OF PRETREATMENT WITH VARIOUS DOSES OF L-ARGININE ON CISPLATIN-INDUCED NEPHROPATHY OF MALE RATS. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;24(6):491-500. Available from: https://sid.ir/paper/36182/en

IEEE: Copy

BAHRAM RASOULIAN, Nassim MoradiRad, MAHBOUBEH JABARI, MARZIEH RASHIDIPOUR, ZEYNAB KHOSHDEL, MASOUD ALIREZAEI, and FARNAZ BEHRAHI, “THE EFFECTS OF PRETREATMENT WITH VARIOUS DOSES OF L-ARGININE ON CISPLATIN-INDUCED NEPHROPATHY OF MALE RATS,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 6, pp. 491–500, 2016, [Online]. Available: https://sid.ir/paper/36182/en

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