EVALUATION OF THE ANTIOXIDANT EFFECT OF CROCIN ON NEONATE BALB/C MOUSE SPERMATOGONIAL STEM CELLS

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SHOKRI A.; BAHARARA J.; AMINI E.

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Journal: JOURNAL OF CELL & TISSUE Year:2016 | Volume:7 | Issue:3 Page(s): 219-229

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Title

EVALUATION OF THE ANTIOXIDANT EFFECT OF CROCIN ON NEONATE BALB/C MOUSE SPERMATOGONIAL STEM CELLS

Author(s)

SHOKRI A. | BAHARARA J. | AMINI E. | Issue Writer Certificate

Keywords

CROCINQ2

ANTIOXIDANTQ2

APOPTOSISQ2

SPERMATOGENIC STEM CELLSQ1

Abstract

Aim: The aim of this study is evaluating the effect of CROCIN as one of saffron bioactive compounds in mice SPERMATOGENIC STEM CELLS.Material and Methods: Balb/c neonate SPERMATOGENIC STEM CELLS were grown in DMEM-F12 medium and were treated with various concentrations of CROCIN (2.5, 5, 10, 20, 40<g/ml) for 6 and 12 days. For detecting SPERMATOGENIC STEM CELLS, assessment cytotoxicity, recognizing viable cells and ANTIOXIDANT capacity have been used alkaline phosphatase assay, MTT assay, AO, DAPI staining, and DCF-DA assay, respectively. Statistical analyses, One-way ANOVA, Duncan test (P£0.05), were conducted using SPSS software.Results: CROCIN in concentrations>20mg/ml exerted no significant toxicity on mice SPERMATOGENIC STEM CELLS in 6 and 12 days treatment. Meanwhile, viability of mice SPERMATOGENIC STEM CELLS was reduced under exposure to 20, 40mg/ml to 21, 24 % in 6 days and 29, 41% in 12 days treatment.Further, evaluations of cell viability by fluorescence microscopy and ANTIOXIDANT potential by fluorimetery have showed protective and ANTIOXIDANT effect of CROCIN after 12 day treatment.Conclusion: CROCIN can be induced protective effect on mice SPERMATOGENIC STEM CELLS, which conducted their effect through minimal effects on cell viability and reducing cell death.

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APA: Copy

SHOKRI, A., BAHARARA, J., & AMINI, E.. (2016). EVALUATION OF THE ANTIOXIDANT EFFECT OF CROCIN ON NEONATE BALB/C MOUSE SPERMATOGONIAL STEM CELLS. JOURNAL OF CELL & TISSUE, 7(3 ), 219-229. SID. https://sid.ir/paper/188883/en

Vancouver: Copy

SHOKRI A., BAHARARA J., AMINI E.. EVALUATION OF THE ANTIOXIDANT EFFECT OF CROCIN ON NEONATE BALB/C MOUSE SPERMATOGONIAL STEM CELLS. JOURNAL OF CELL & TISSUE[Internet]. 2016;7(3 ):219-229. Available from: https://sid.ir/paper/188883/en

IEEE: Copy

A. SHOKRI, J. BAHARARA, and E. AMINI, “EVALUATION OF THE ANTIOXIDANT EFFECT OF CROCIN ON NEONATE BALB/C MOUSE SPERMATOGONIAL STEM CELLS,” JOURNAL OF CELL & TISSUE, vol. 7, no. 3 , pp. 219–229, 2016, [Online]. Available: https://sid.ir/paper/188883/en

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