MOLECULAR AND CELLULAR BASIS OF HUMAN CANCER

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PARSA N.

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Journal Paper

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Journal: JOURNAL OF CELL & TISSUE Year:2012 | Volume:2 | Issue:4 Page(s): 365-376

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Information Journal Paper

Title

MOLECULAR AND CELLULAR BASIS OF HUMAN CANCER

Author(s)

PARSA N. | Issue Writer Certificate

Keywords

BIOLOGICAL CARCINOGENSQ2

HUMAN CANCERSQ2

Abstract

During the past 30 years, researchers have made a remarkable progress in identifying the biological (bacteria, viruses), biochemical (chemical compounds) and biophysical (ionizing radiation) cause of human cancer. The term “Cancer” refers to 277 forms of cancer diseases.Scientists have determined the process of cancer formation from a consequence of accumulating multiple mutations in human genome. These genetic disruptions would eventually change the normal process of cellular proliferations and differentiation.The genetic alterations are frequently indicative of poor prognosis for most HUMAN CANCERS.Both nonhereditary and hereditary cancers are caused by genetic disorders that change the cellular growth control system.Genes associated with human cancer formation include four classes of genes: 1. Oncogenes (which increasing their activities end to uncontrollable growth of cells), 2. Tumor suppressor genes, 3. DNA repairing genes, 4. Apoptotic genes.Over activated oncogenes which cause cellular proliferation. In contrast, inactivated tumor suppressor genes lose their inhibitory effect which is crucial to prevent inappropriate growth. DNA repairing proteins fix the damage and apoptotic proteins cause the pre-cancer cell to commit suicide.We have over millions of genes in each somatic cell of our body. After sequencing all human genome in 2003, we noticed that only 23, 500 genes are active which encode over 400, 000 proteins needed for physiological functions.99.9% of genome is identical in all humans worldwide. Only 0.1% of the whole genome differ which cause the genetic variations.Up to 93% of all HUMAN CANCERS are non-hereditary and the remaining 7% are hereditary. A wealth of information has been indicated by the potential use of bioinformatics and molecular techniques for cancer screening, prognosis and monitoring of the efficacy of anticancer therapies. In recent years, molecular genetics have greatly increased our understanding of the basic mechanisms in cancer development. The essential outcome of these molecular studies is that the cancer can be considered as the genetic disease.

Cites

GASTROINTESTINAL CANCERS IN IRAN: IRANIAN SCIENTISTS APPROACH TO GASTROINTESTINAL CANCERS RESEARCHES IN INTERNATIONAL DATABASES

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APA: Copy

PARSA, N.. (2012). MOLECULAR AND CELLULAR BASIS OF HUMAN CANCER. JOURNAL OF CELL & TISSUE, 2(4), 365-376. SID. https://sid.ir/paper/188952/en

Vancouver: Copy

PARSA N.. MOLECULAR AND CELLULAR BASIS OF HUMAN CANCER. JOURNAL OF CELL & TISSUE[Internet]. 2012;2(4):365-376. Available from: https://sid.ir/paper/188952/en

IEEE: Copy

N. PARSA, “MOLECULAR AND CELLULAR BASIS OF HUMAN CANCER,” JOURNAL OF CELL & TISSUE, vol. 2, no. 4, pp. 365–376, 2012, [Online]. Available: https://sid.ir/paper/188952/en

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