PROTECTIVE EFFECT OF ROYAL JELLY AND VITAMIN C AGAINST PHENYLHYDRAZINE- INDUCED NEPHROPATHY IN MICE: HISTOLOGICAL STUDY

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ANBARA H.; SHAHROOZ R.; SHALIZAR JALALI A.; TOUNI S.R.

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Journal: JOURNAL OF CELL & TISSUE Year:2017 | Volume:7 | Issue:4 Page(s): 417-428

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Title

PROTECTIVE EFFECT OF ROYAL JELLY AND VITAMIN C AGAINST PHENYLHYDRAZINE- INDUCED NEPHROPATHY IN MICE: HISTOLOGICAL STUDY

Author(s)

ANBARA H. | SHAHROOZ R. | SHALIZAR JALALI A. | TOUNI S.R. | Issue Writer Certificate

Keywords

ROYAL JELLYQ1

VITAMIN CQ2

PHENYLHYDRAZINEQ1

KIDNEYQ2

MOUSEQ2

Abstract

Aim: The aim of the present study was to investigate the effects of ROYAL JELLY (RJ) and VITAMIN C (vit C) against PHZ-induced nephropathy in mice.Material and Methods: Adult male mice were randomly divided into eight eight-membered groups.The PHZ was administered to four groups of mice at a dose of 60 mg/kg per 48 hours intraperitoneally for 35 days. Three of these groups received vit C (250 mg/kg per day) intraperitoneally, RJ (100 mg/kg per day) orally and vit C+RJ with same doses, four hours before PHZ administration, respectively. A vehicle-treated control group and vit C, RJ and vit C+RJ control groups were also included. Serum and renal tissue samples were collected 24 hours after the last treatment and subjected to biochemical and histological examinations, respectively. The data were analyzed by one-way analysis of variance followed by Duncan test for post hoc comparisons.Results: The PHZ treatment caused a significant (P<0.05) increased malondealdehyde concentration in serum, but decreased total antioxidant capacity of it. Moreover, PHZ significantly (P<0.05) increased luminal diameter of proximal convoluted tubule, while decreased (P<0.05) their epithelial cells height. Considerably, co-treatment of vit C and RJ improved all changes in the above-mentioned parameters.Conclusion: The Vit C and RJ can minimize PHZ-induced nephropathy in MOUSE through oxidative reactions inhibition.

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APA: Copy

ANBARA, H., SHAHROOZ, R., SHALIZAR JALALI, A., & TOUNI, S.R.. (2017). PROTECTIVE EFFECT OF ROYAL JELLY AND VITAMIN C AGAINST PHENYLHYDRAZINE- INDUCED NEPHROPATHY IN MICE: HISTOLOGICAL STUDY. JOURNAL OF CELL & TISSUE, 7(4 ), 417-428. SID. https://sid.ir/paper/189057/en

Vancouver: Copy

ANBARA H., SHAHROOZ R., SHALIZAR JALALI A., TOUNI S.R.. PROTECTIVE EFFECT OF ROYAL JELLY AND VITAMIN C AGAINST PHENYLHYDRAZINE- INDUCED NEPHROPATHY IN MICE: HISTOLOGICAL STUDY. JOURNAL OF CELL & TISSUE[Internet]. 2017;7(4 ):417-428. Available from: https://sid.ir/paper/189057/en

IEEE: Copy

H. ANBARA, R. SHAHROOZ, A. SHALIZAR JALALI, and S.R. TOUNI, “PROTECTIVE EFFECT OF ROYAL JELLY AND VITAMIN C AGAINST PHENYLHYDRAZINE- INDUCED NEPHROPATHY IN MICE: HISTOLOGICAL STUDY,” JOURNAL OF CELL & TISSUE, vol. 7, no. 4 , pp. 417–428, 2017, [Online]. Available: https://sid.ir/paper/189057/en

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