STUDY OF THE PROTECTIVE EFFECT OF CO-ADMINISTRATING OF VITAMIN C AND ROYAL JELLY ON SPERM QUALITY AND SERUM PARAMETERS IN MICE (NMRI) FOLLOWING PHENYLHYDRAZINE INDUCED HEMOLYTIC ANEMIA

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ANBARA H.; SHAHROOZ R.; RAZI M.; MALEKINEJAD H.

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Journal: Journal of Shahrekord University of Medical Sciences Year:2016 | Volume:17 | Issue:5 Page(s): 110-120

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Title

STUDY OF THE PROTECTIVE EFFECT OF CO-ADMINISTRATING OF VITAMIN C AND ROYAL JELLY ON SPERM QUALITY AND SERUM PARAMETERS IN MICE (NMRI) FOLLOWING PHENYLHYDRAZINE INDUCED HEMOLYTIC ANEMIA

Author(s)

ANBARA H. | SHAHROOZ R. | RAZI M. | MALEKINEJAD H. | Issue Writer Certificate

Keywords

HEMOLYTIC ANEMIAQ2

PHENYLHYDRAZINEQ1

VITAMIN CQ2

ROYAL JELLYQ2

SPERM QUALITYQ2

Abstract

Background and aims: The reduction in blood flow may result pathological changes in testicular and spermatogenesis function. Moreover, free iron ions result of lysing red blood cells and consequently the increase in iron ions content of testes leads to oxidative stress with reproductive system dysfunction. So, the present study was aimed to evaluate the protective effect of the simultaneous use of ROYAL JELLY (RJ) and VITAMIN C (Vit C) on HEMOLYTIC ANEMIA condition along with decomposition of red blood cells.Methods: In this experimental study, 32 mature mice weighting 20-25 gr were divide into 4 groups including control group received normal saline (0.2 mL, IP) with intraperitoneal injection, sham control group administered with PHENYLHYDRAZINE (PHZ) (6 mg/100g , IP), PHZ+ Vit C with (250 mg/kg, IP)+ RJ (100 mg/kg,) group orally and RJ+Vit C group. After 35 days, blood samples were obtained from heart with the evaluation of serum levels of total antioxidant capacity (TAC) and malondialdehyde (MDA). Also, the SPERM QUALITY including sperm motility, viability, sperm count, chromatin condensation and DNA damage was assessed.Results: There was a significant reduction in TAC level of PHZ group in the present study, and co-administrating Vit C and RJ in receiver group of antioxidants could prevent this decrease. Moreover, the PHZ caused the serum level of MDA is increased. Meanwhile, co-administrating the Vit C and RJ diminished MDA in PHZ-administrated animals. Finally, co-administrating the Vit C and RJ by scavengering of free radicals resulted in remarkable enhancement in quality of sperm parameters (P<0.05).Conclusion: PHZ can disorder sperm parameters through inducing oxidative stress. Co-administrating of the Vit C and RJ may be significantly up-regulated the serum TAC level and down regulating of MDA promoted the SPERM QUALITY.

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APA: Copy

ANBARA, H., SHAHROOZ, R., RAZI, M., & MALEKINEJAD, H.. (2016). STUDY OF THE PROTECTIVE EFFECT OF CO-ADMINISTRATING OF VITAMIN C AND ROYAL JELLY ON SPERM QUALITY AND SERUM PARAMETERS IN MICE (NMRI) FOLLOWING PHENYLHYDRAZINE INDUCED HEMOLYTIC ANEMIA. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 17(5), 110-120. SID. https://sid.ir/paper/58933/en

Vancouver: Copy

ANBARA H., SHAHROOZ R., RAZI M., MALEKINEJAD H.. STUDY OF THE PROTECTIVE EFFECT OF CO-ADMINISTRATING OF VITAMIN C AND ROYAL JELLY ON SPERM QUALITY AND SERUM PARAMETERS IN MICE (NMRI) FOLLOWING PHENYLHYDRAZINE INDUCED HEMOLYTIC ANEMIA. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;17(5):110-120. Available from: https://sid.ir/paper/58933/en

IEEE: Copy

H. ANBARA, R. SHAHROOZ, M. RAZI, and H. MALEKINEJAD, “STUDY OF THE PROTECTIVE EFFECT OF CO-ADMINISTRATING OF VITAMIN C AND ROYAL JELLY ON SPERM QUALITY AND SERUM PARAMETERS IN MICE (NMRI) FOLLOWING PHENYLHYDRAZINE INDUCED HEMOLYTIC ANEMIA,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 17, no. 5, pp. 110–120, 2016, [Online]. Available: https://sid.ir/paper/58933/en

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