INVESTIGATING THE EFFECTS OF HYDROCORTISONE HORMONE ON INDUCED CLASTOGENICAL CHROMOSOMAL ABNORMALITIES ON L929 CELL LINE USING MICRONUCLEUS ASSAY ON BINUCLEATED CELLS

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SAMSAMI Y.; HADDAD F.; MOGHADAM MATIN M.; SOLEYMANIFARD SH.; ABBASPOUR H.

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Journal: JOURNAL OF CELL & TISSUE Year:2015 | Volume:6 | Issue:3 Page(s): 249-256

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Title

INVESTIGATING THE EFFECTS OF HYDROCORTISONE HORMONE ON INDUCED CLASTOGENICAL CHROMOSOMAL ABNORMALITIES ON L929 CELL LINE USING MICRONUCLEUS ASSAY ON BINUCLEATED CELLS

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Keywords

STRESSQ2

HYDROCORTISONEQ2

L929Q2

GAMMA RAYQ2

MICRONUCLEUSQ2

Abstract

Aim: In this study the effects of STRESS on induction of structural chromosomal abnormalities on L929 cell line using MICRONUCLEUS assay on cytokinesis-blocked binucleated cells were investigated in vitro.Material and methods: L929 cells were cultured in DMEM containing 10% FBS. The cells were divided into four groups including; control, 2Gy gamma-irradiated cells, and cells treated with doses of 25, 50 and 100 mg/ml HYDROCORTISONE, and cells co-treated with these three doses of HYDROCORTISONE and irradiation. The treated cells were harvested, stained and chromosome abnormalities were scored using MICRONUCLEUS assay.Results: Results showed that HYDROCORTISONE did not induce micronuclei as compared to the control group. However, the frequency of micronuclei in cells co-treated with doses of HYDROCORTISONE and irradiation was significantly higher than cells treated only with gamma irradiation (P<0.05).Conclusion: According to the data of this study, STRESS hormones are not able to induce any chromosomal abnormalities; however, they are able to increase the cell susceptibility to clastogenic effects of irradiation.

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APA: Copy

SAMSAMI, Y., HADDAD, F., MOGHADAM MATIN, M., SOLEYMANIFARD, SH., & ABBASPOUR, H.. (2015). INVESTIGATING THE EFFECTS OF HYDROCORTISONE HORMONE ON INDUCED CLASTOGENICAL CHROMOSOMAL ABNORMALITIES ON L929 CELL LINE USING MICRONUCLEUS ASSAY ON BINUCLEATED CELLS. JOURNAL OF CELL & TISSUE, 6(3), 249-256. SID. https://sid.ir/paper/189076/en

Vancouver: Copy

SAMSAMI Y., HADDAD F., MOGHADAM MATIN M., SOLEYMANIFARD SH., ABBASPOUR H.. INVESTIGATING THE EFFECTS OF HYDROCORTISONE HORMONE ON INDUCED CLASTOGENICAL CHROMOSOMAL ABNORMALITIES ON L929 CELL LINE USING MICRONUCLEUS ASSAY ON BINUCLEATED CELLS. JOURNAL OF CELL & TISSUE[Internet]. 2015;6(3):249-256. Available from: https://sid.ir/paper/189076/en

IEEE: Copy

Y. SAMSAMI, F. HADDAD, M. MOGHADAM MATIN, SH. SOLEYMANIFARD, and H. ABBASPOUR, “INVESTIGATING THE EFFECTS OF HYDROCORTISONE HORMONE ON INDUCED CLASTOGENICAL CHROMOSOMAL ABNORMALITIES ON L929 CELL LINE USING MICRONUCLEUS ASSAY ON BINUCLEATED CELLS,” JOURNAL OF CELL & TISSUE, vol. 6, no. 3, pp. 249–256, 2015, [Online]. Available: https://sid.ir/paper/189076/en

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