EFFECTS OF AQUEOUS EXTRACT OF GLYCYRRHIZA GLABRA ROOT AGAINST LIPID DYSFUNCTION AND HEPATIC TISSUE CHANGES INDUCED BY THIOACETAMIDE IN MALE RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOGHADAMNIA D.; MOKHTARI M.; KHATAMSAZ S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES) Year:2016 | Volume:9 | Issue:1 (32) Page(s): 1-8

Download Full-Text

Persian Verion

View:

1,453

Download:

Cites:

Information Journal Paper

Title

EFFECTS OF AQUEOUS EXTRACT OF GLYCYRRHIZA GLABRA ROOT AGAINST LIPID DYSFUNCTION AND HEPATIC TISSUE CHANGES INDUCED BY THIOACETAMIDE IN MALE RATS

Author(s)

MOGHADAMNIA D. | MOKHTARI M. | KHATAMSAZ S. | Issue Writer Certificate

Keywords

GLYCYRRHIZA GLABRAQ2

THIOACETAMIDEQ2

LIPID DYSFUNCTIONQ2

GLUCOSEQ2

MALE RATQ2

Abstract

Introduction & Objective: THIOACETAMIDE cause hepatocellular carcinoma and LIPID DYSFUNCTION. The plant phenolic compounds such as flavonoids have a important role in the treatment of many disease. The present study was done to evaluate effects of aqueous extract of GLYCYRRHIZA GLABRA root against LIPID DYSFUNCTION and hepatic tissue changes induced by THIOACETAMIDE in MALE RATs.Materials and Methods: 35 MALE RATs were divided into five groups of seven: Control group. Animals of this group underwent no stress such as injection, oral gavage and etc. Sham group. Animals of this group received 150 mg/kg of THIOACETAMIDE intrapertionealy in a single dose for 3 months. Experimental group 1,2,3. Animals of this groups received 100,200,300 mg/kg of aqueous extract of GLYCYRRHIZA GLABRA root orally per day for 3 months and then 150 mg/kg of THIOACETAMIDE intrapertionealy in a single dose. All animals bled after 3 months .The provided blood samples were tested for total cholesterol, LDL and HDL cholesterol, triglyceride and GLUCOSE serum levels by enzymatic methods. The pathological examination of hepatic tissue samples were done after hematoxylin - eosin staining.Results: Pretreatmen with 100,300 mg/kg of aqueous extract of GLYCYRRHIZA GLABRA root significan decreased the serum levels of total choesterol comparing with THIOACETAMIDE group. Pretreatmen with the aqueous extract of GLYCYRRHIZA GLABRA root at all doses increased the serum levels of GLUCOSE comparing with THIOACETAMIDE group but there was no significant difference. Pretreatmen with the aqueous extract of GLYCYRRHIZA GLABRA root at all doses showed no significant difference in serum levels of LDL, HDLcholesterol and triglyceride comparing with THIOACETAMIDE group. In all experimental groups the hepatic tissue changes induced by THIOACETAMIDE improved which were dose dependent (p£.05).Conclusion: Therefore, the result show that the protective effects of aqueous extract of GLYCYRRHIZA GLABRA root against LIPID DYSFUNCTION and hepatic tissue induced by THIOACETAMIDE in MALE RATs. The protective effects of this extract can be due to the presence of flavonoids, chalcones, phytosterols compounds.

Cites

No record.

References

No record.

Cite

APA: Copy

MOGHADAMNIA, D., MOKHTARI, M., & KHATAMSAZ, S.. (2016). EFFECTS OF AQUEOUS EXTRACT OF GLYCYRRHIZA GLABRA ROOT AGAINST LIPID DYSFUNCTION AND HEPATIC TISSUE CHANGES INDUCED BY THIOACETAMIDE IN MALE RATS. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), 9(1 (32)), 1-8. SID. https://sid.ir/paper/191620/en

Vancouver: Copy

MOGHADAMNIA D., MOKHTARI M., KHATAMSAZ S.. EFFECTS OF AQUEOUS EXTRACT OF GLYCYRRHIZA GLABRA ROOT AGAINST LIPID DYSFUNCTION AND HEPATIC TISSUE CHANGES INDUCED BY THIOACETAMIDE IN MALE RATS. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES)[Internet]. 2016;9(1 (32)):1-8. Available from: https://sid.ir/paper/191620/en

IEEE: Copy

D. MOGHADAMNIA, M. MOKHTARI, and S. KHATAMSAZ, “EFFECTS OF AQUEOUS EXTRACT OF GLYCYRRHIZA GLABRA ROOT AGAINST LIPID DYSFUNCTION AND HEPATIC TISSUE CHANGES INDUCED BY THIOACETAMIDE IN MALE RATS,” JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), vol. 9, no. 1 (32), pp. 1–8, 2016, [Online]. Available: https://sid.ir/paper/191620/en

Related Journal Papers