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Information Journal Paper

Title

PROTECTIVE EFFECTS OF FISH OIL OMEGA3 SUPPLEMENTS AND AQUEOUS EXTRACT OF GLYCYRRHIZA GLABRA ROOT AGAINST CHANGES OF LIVER ENZYMES LEVELS INDUCED BY THIOACETAMIDE IN MALE RATS

Pages

  171-177

Abstract

 Background: THIOACETAMIDE is a liver toxin that causes centrilobular necrosis. In this study, the protective effect of fish oil OMEGA3 supplements and aqueous extract of GLYCYRRHIZA GLABRA ROOT against disorder in LIVER ENZYMES level induced by THIOACETAMIDE in MALE RATS was investigated. Materials and methods: In this experimental study, 63 MALE RATS were divided into 9 groups: The control group, the sham group, the THIOACETAMIDE group, the experimental groups 1-6. Experimental groups received a daily dose of 100, 200 and 300 mg/kg fish oil omega-3 supplements and the aqueous extract of GLYCYRRHIZA GLABRA ROOT orally respectively for 3 month followed by an inter peritoneal dose of 150 mg/kg THIOACETAMIDE at the end of the experiment. The serum levels of SGOT, SGPT, ALP, GGT and LDH were measured. Results: The serum level of SGPT showed a significant decrease in the experimental groups 1, 5 and 6 compared to the group received THIOACETAMIDE. The serum level of GGT showed a significant decrease in the experimental groups 1, 2, 5 and 6 compared to the group received THIOACETAMIDE. The serum levels of SGOT, ALP and LDH in all experimental groups did not show significant changes compared to the group received THIOACETAMIDE (P<0.05). Conclusion: Fish oil OMEGA3 supplements and aqueous extract of GLYCYRRHIZA GLABRA ROOT had protective effects against disorder in LIVER ENZYMES level induced by THIOACETAMIDE in MALE RATS.

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    APA: Copy

    MOGHADAMNIA, DAVOUD, MOKHTARI, MOKHTAR, & KHATAMSAZ, SAEED. (2017). PROTECTIVE EFFECTS OF FISH OIL OMEGA3 SUPPLEMENTS AND AQUEOUS EXTRACT OF GLYCYRRHIZA GLABRA ROOT AGAINST CHANGES OF LIVER ENZYMES LEVELS INDUCED BY THIOACETAMIDE IN MALE RATS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 27(3), 171-177. SID. https://sid.ir/paper/98644/en

    Vancouver: Copy

    MOGHADAMNIA DAVOUD, MOKHTARI MOKHTAR, KHATAMSAZ SAEED. PROTECTIVE EFFECTS OF FISH OIL OMEGA3 SUPPLEMENTS AND AQUEOUS EXTRACT OF GLYCYRRHIZA GLABRA ROOT AGAINST CHANGES OF LIVER ENZYMES LEVELS INDUCED BY THIOACETAMIDE IN MALE RATS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2017;27(3):171-177. Available from: https://sid.ir/paper/98644/en

    IEEE: Copy

    DAVOUD MOGHADAMNIA, MOKHTAR MOKHTARI, and SAEED KHATAMSAZ, “PROTECTIVE EFFECTS OF FISH OIL OMEGA3 SUPPLEMENTS AND AQUEOUS EXTRACT OF GLYCYRRHIZA GLABRA ROOT AGAINST CHANGES OF LIVER ENZYMES LEVELS INDUCED BY THIOACETAMIDE IN MALE RATS,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 27, no. 3, pp. 171–177, 2017, [Online]. Available: https://sid.ir/paper/98644/en

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