STUDY THE RESPIRATORY BURST OF PERIPHERAL BLOOD MONOCYTES IN THE PRESENCE OF SACCHAROMYCES CEREVISIAE β-GLUCAN IN PATIENTS WITH DIABETES

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A.ASADIRAD M.H.; TOFIGHI A.; SHAHNAVAZ ALI

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Journal: JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES) Year:2015 | Volume:8 | Issue:1 (28) Page(s): 41-47

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Title

STUDY THE RESPIRATORY BURST OF PERIPHERAL BLOOD MONOCYTES IN THE PRESENCE OF SACCHAROMYCES CEREVISIAE β-GLUCAN IN PATIENTS WITH DIABETES

Author(s)

A.ASADIRAD M.H. | TOFIGHI A. | SHAHNAVAZ ALI | Issue Writer Certificate

Keywords

DIABETESQ2

BETA-GLUCANQ2

OXIDATIVE BURSTQ2

SACCHAROMYCES CEREVISIAEQ1

Abstract

Introduction & Objective: DIABETES mellitus is a chronic disease with epidemic potential. Diabetics are faced with complications of metabolic disorders and defects in their immune system. The use of immune system stimulating agents, such as BETA-GLUCAN is one of the researcher's interests to reduce the complications of DIABETES. The present study aimed to investigate the effect of beta- glucan cell wall of SACCHAROMYCES CEREVISIAE strains AT-3 on the respiratory burst of peripheral blood monocytes in patients with DIABETES.Material and Methods: Peripheral blood of 53 patients with DIABETES and 50 nondiabetic patients with an average of 39 years were sampled from Vali-Asr Hospital of Zanjan. Cells of SACCHAROMYCES CEREVISIAE strain AT-3 were broken using sonikator. The cell wall was isolated. Beta- glucan was extracted from the wall. Nitro Blue Tetrazolium test was used to evaluate the respiratory burst of monocytes stimulated with beta glucan. Data were analyzed using multi-way ANOVA.Results: The results indicated that the respiratory burst of stimulated monocytes was increased in both men and women. The effect was dose dependent and it was significantly higher in women (p˂0.01).Conclusion: Beta- glucan extracted from SACCHAROMYCES CEREVISIAE strain AT-3 is a potent immune system activator.

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APA: Copy

A.ASADIRAD, M.H., TOFIGHI, A., & SHAHNAVAZ, ALI. (2015). STUDY THE RESPIRATORY BURST OF PERIPHERAL BLOOD MONOCYTES IN THE PRESENCE OF SACCHAROMYCES CEREVISIAE β-GLUCAN IN PATIENTS WITH DIABETES. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), 8(1 (28)), 41-47. SID. https://sid.ir/paper/191794/en

Vancouver: Copy

A.ASADIRAD M.H., TOFIGHI A., SHAHNAVAZ ALI. STUDY THE RESPIRATORY BURST OF PERIPHERAL BLOOD MONOCYTES IN THE PRESENCE OF SACCHAROMYCES CEREVISIAE β-GLUCAN IN PATIENTS WITH DIABETES. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES)[Internet]. 2015;8(1 (28)):41-47. Available from: https://sid.ir/paper/191794/en

IEEE: Copy

M.H. A.ASADIRAD, A. TOFIGHI, and ALI SHAHNAVAZ, “STUDY THE RESPIRATORY BURST OF PERIPHERAL BLOOD MONOCYTES IN THE PRESENCE OF SACCHAROMYCES CEREVISIAE β-GLUCAN IN PATIENTS WITH DIABETES,” JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), vol. 8, no. 1 (28), pp. 41–47, 2015, [Online]. Available: https://sid.ir/paper/191794/en

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