MOLECULAR STUDY OF COMMON GENES IN THE DEVELOPMENT CELLS AND CANCER AT TISSUE OF PATIENTS WITH COLORECTAL CANCER

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MORADIFARD SH.; MOHAMMAD GANJI SH.; CHEHZARIN M.

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Paper Information

Journal: JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES) Year:2015 | Volume:8 | Issue:4 (31) Page(s): 61-66

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Title

MOLECULAR STUDY OF COMMON GENES IN THE DEVELOPMENT CELLS AND CANCER AT TISSUE OF PATIENTS WITH COLORECTAL CANCER

Author(s)

MORADIFARD SH. | MOHAMMAD GANJI SH. | CHEHZARIN M. | Issue Writer Certificate

Keywords

CMYCQ2

AXIN1Q2

GENE EXPRESSIONQ1

COLORECTAL CANCERQ1

RT-PCRQ2

Abstract

Inroduction & Objective: COLORECTAL CANCER (CRC) is the third most common cancer in men and the second most common cancer in women in the world. Axin gene includes AXIN1 and axin2. The C-myc and other genes of this family encode transcription factors that play a vital role in cell proliferation, growth, differentiation and apoptosis. The aim of this study was to evaluate semi-quantitative genes expression of AXIN1, CMYC in mRNA tissue of Iranian patients with CRC and checking the communication ON or OFF of this genes in each tumor stages and pathologic factors of patients.Material and Methods: Therefore, we have done RT-PCR with specific primers for AXIN1, CMYC and b- actin genes on the 54 tumor and 41 normal tissues as fresh samples which obtained from 54 unrelated patients referred to Imam Khomeini Hospital.Results: According the results, 55% of the samples were ON and 45% of the samples were OFF for AXIN1 GENE EXPRESSION and 87.5% of the samples were ON and 12.5% of the samples were OFF for CMYC GENE EXPRESSION respectively. Statistical analysis with SPSS, T-test and X2 showed that there is a significant differences of the AXIN1 and CMYC expression between two groups of samples; normal, tumor (P <0.05).Conclusion: According the results, 55% of the samples were ON and 45% of the samples were OFF for AXIN1 GENE EXPRESSION and 87.5% of the samples were ON and 12.5% of the samples were OFF for CMYC GENE EXPRESSION respectively. Statistical analysis with SPSS, T-test and X2 showed that there is a significant differences of the AXIN1 and CMYC expression between two groups of samples; normal, tumor (P <0.05).

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APA: Copy

MORADIFARD, SH., MOHAMMAD GANJI, SH., & CHEHZARIN, M.. (2015). MOLECULAR STUDY OF COMMON GENES IN THE DEVELOPMENT CELLS AND CANCER AT TISSUE OF PATIENTS WITH COLORECTAL CANCER. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), 8(4 (31)), 61-66. SID. https://sid.ir/paper/191812/en

Vancouver: Copy

MORADIFARD SH., MOHAMMAD GANJI SH., CHEHZARIN M.. MOLECULAR STUDY OF COMMON GENES IN THE DEVELOPMENT CELLS AND CANCER AT TISSUE OF PATIENTS WITH COLORECTAL CANCER. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES)[Internet]. 2015;8(4 (31)):61-66. Available from: https://sid.ir/paper/191812/en

IEEE: Copy

SH. MORADIFARD, SH. MOHAMMAD GANJI, and M. CHEHZARIN, “MOLECULAR STUDY OF COMMON GENES IN THE DEVELOPMENT CELLS AND CANCER AT TISSUE OF PATIENTS WITH COLORECTAL CANCER,” JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), vol. 8, no. 4 (31), pp. 61–66, 2015, [Online]. Available: https://sid.ir/paper/191812/en

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