Study of FGF14 gene expression and cancer progression in colorectal cancer tissue samples

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Jalali Tafti Homayoun; HASHEMI MEHRDAD; ALIMOHAMMADZADEH KHALIL

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Paper Information

Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2019 | Volume:29 | Issue:3 Page(s): 210-215

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Information Journal Paper

Title

Study of FGF14 gene expression and cancer progression in colorectal cancer tissue samples

Author(s)

Jalali Tafti Homayoun | HASHEMI MEHRDAD | ALIMOHAMMADZADEH KHALIL | Issue Writer Certificate

Keywords

Colorectal cancerQ2

FGF14Q1

Real-Time PCRQ2

Gene expressionQ2

Tumor stageQ2

MetastasisQ2

Abstract

Background: Colorectal cancer is one of the main causes of cancer death and the third most common malignant cancer worldwide. FGF14 is a member of the large family of fibroblast growth factors. These factors control a wide range of biological functions, including cell proliferation, survival, migration and differentiation that disturbing their expression can lead to cancer. The purpose of this study was to determine the expression of FGF14 in Colorectal cancer tissue samples and adjacent healthy tissues. Materials and methods: In this case-control study, 35 patients with Colorectal cancer and adjacent tumor tissue were classified based on their clinical and pathological characteristics. The expression was studied by real time PCR reaction method. Results: The relative expression levels of FGF14 in tumoral tissues were shown to be significantly increased compared with their adjacent normal tissues. There was significant correlation between the relative expression level of FGF14 in tumoral tissues and clinicopathological features, such as cancer staging, tumor size, and Metastasis. Conclusion: Increased expression of FGF14 in Colorectal cancer tissue compared to the adjacent normal tissues is associated with the cancer progression and development relevant clinicopathological features. Therefore, it may play an important role in the pathophysiology of Colorectal cancer.

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APA: Copy

Jalali Tafti, Homayoun, HASHEMI, MEHRDAD, & ALIMOHAMMADZADEH, KHALIL. (2019). Study of FGF14 gene expression and cancer progression in colorectal cancer tissue samples. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 29(3 ), 210-215. SID. https://sid.ir/paper/98867/en

Vancouver: Copy

Jalali Tafti Homayoun, HASHEMI MEHRDAD, ALIMOHAMMADZADEH KHALIL. Study of FGF14 gene expression and cancer progression in colorectal cancer tissue samples. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2019;29(3 ):210-215. Available from: https://sid.ir/paper/98867/en

IEEE: Copy

Homayoun Jalali Tafti, MEHRDAD HASHEMI, and KHALIL ALIMOHAMMADZADEH, “Study of FGF14 gene expression and cancer progression in colorectal cancer tissue samples,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 29, no. 3 , pp. 210–215, 2019, [Online]. Available: https://sid.ir/paper/98867/en

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