Effect of aquatic garlic (Allium sativum L. ) extract on the survival of breast cancer cells (MCF-7) and non-cancerous cells of mouse fibroblasts (L929)

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HASSANZADEH ZAHRA; Mikaeili Agah Elmira; ASADI ASADOLLAH; Bagheri valmi Kobra

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Journal: JOURNAL OF DEVELOPMENTAL BIOLOGY Year:2019 | Volume:11 | Issue:1 Page(s): 45-52

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Information Journal Paper

Title

Effect of aquatic garlic (Allium sativum L. ) extract on the survival of breast cancer cells (MCF-7) and non-cancerous cells of mouse fibroblasts (L929)

Author(s)

HASSANZADEH ZAHRA | Mikaeili Agah Elmira | ASADI ASADOLLAH | Bagheri valmi Kobra | Issue Writer Certificate

Keywords

Breast Cancer CellQ1

Mouse Fibroblast CellQ1

Aqueous Extract of GarlicQ1

CytotoxicityQ1

Abstract

Garlic has been known worldwide as a dietary constituent with many pharmacological effects in humans for centuries. The aim of this study was to compare the Cytotoxicity effect of the Aqueous Extract of Garlic on Breast Cancer Cells (MCF-7) and non-cancerous normal cells (L929). After culture and treatment of cells with different concentrations of extract for 24, 48 and 72 hours, the cell morphology was investigated by invert microscopy and the toxic effect of the extract was determined by MTT (3-4, 5 dimethylthiazole 2-yl 5, 2-diphenyl tetrazolium). Microscopic observations showed no change in both cell lines within 24 hours. These changes appeared after 48 and 72 hours in cancerous cells and increased after 72 hours, but no significant changes were observed in healthy cells. At the same time, the results of MTT showed that the mortality rate was significant at high doses at 24 and 48 hours (P <0. 001), and in 72 hours it was very intense and survival rate reached 48% at the highest dose. However, at 24 and 48 hours, we did not see significant death in non-cancerous cells, but at higher doses of 4000 μ g/ml in 72 hours, death increased significantly (P <0. 001) but did not exceed 19%. Therefore, Aqueous Extract of Garlic has a greater effect on Breast Cancer Cells than normal cells, and can be used to prevent cancer or as a supplement to chemotherapy in the future.

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APA: Copy

HASSANZADEH, ZAHRA, Mikaeili Agah, Elmira, ASADI, ASADOLLAH, & Bagheri valmi, Kobra. (2019). Effect of aquatic garlic (Allium sativum L. ) extract on the survival of breast cancer cells (MCF-7) and non-cancerous cells of mouse fibroblasts (L929). JOURNAL OF DEVELOPMENTAL BIOLOGY, 11(1 ), 45-52. SID. https://sid.ir/paper/193115/en

Vancouver: Copy

HASSANZADEH ZAHRA, Mikaeili Agah Elmira, ASADI ASADOLLAH, Bagheri valmi Kobra. Effect of aquatic garlic (Allium sativum L. ) extract on the survival of breast cancer cells (MCF-7) and non-cancerous cells of mouse fibroblasts (L929). JOURNAL OF DEVELOPMENTAL BIOLOGY[Internet]. 2019;11(1 ):45-52. Available from: https://sid.ir/paper/193115/en

IEEE: Copy

ZAHRA HASSANZADEH, Elmira Mikaeili Agah, ASADOLLAH ASADI, and Kobra Bagheri valmi, “Effect of aquatic garlic (Allium sativum L. ) extract on the survival of breast cancer cells (MCF-7) and non-cancerous cells of mouse fibroblasts (L929),” JOURNAL OF DEVELOPMENTAL BIOLOGY, vol. 11, no. 1 , pp. 45–52, 2019, [Online]. Available: https://sid.ir/paper/193115/en

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