PROTECTIVE EFFECT OF MELATONIN ON SPINAL CORD DAMAGE AFTER GAMMA IRRADIATION

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MINAEE B.; AGHAZADE S.; AZARNIA M.

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Paper Information

Journal: JOURNAL OF DEVELOPMENTAL BIOLOGY Year:2009 | Volume:1 | Issue:3 Page(s): 39-44

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Information Journal Paper

Title

PROTECTIVE EFFECT OF MELATONIN ON SPINAL CORD DAMAGE AFTER GAMMA IRRADIATION

Author(s)

MINAEE B. | AGHAZADE S. | AZARNIA M. | Issue Writer Certificate

Keywords

MELATONINQ1

FREE RADICALQ2

RADIATION PROTECTIONQ3

NQ3

DAQ3

GSQ3

Abstract

Radiation causes serious DAmages in spinal cord and few agents are used for protection. In this study, Considered Neuro-radioprotective effect of MELATONIN on the cervical spinal cord.32 male adult. Wistar albino rats weighing 200-250 g were used. They were divided into four groups of 6 animals consisted of control, MELATONIN (30 mg/kg per DAy), radiation (single Gamma dose of l0 Gy) and the group that received radiation plus MELATONIN. After 72 hours, all rats were sacrificed fbr histopathological and analysis of malondialdehyde, glutathione and protein biochemicals.Malondialdehyde and protein levels u'ere decreased after MELATONIN treatment while glutathione level, was Increased (p<0.005). Overall histopathological changes were markedly decreased after rnelatonin treatment in comparison to radiation group (p<0.05). ln conclusion MELATONIN may be useful in preventing the spinal cord against radiation toxicity due to its Potential of free oxygen radical scavenging.

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APA: Copy

MINAEE, B., AGHAZADE, S., & AZARNIA, M.. (2009). PROTECTIVE EFFECT OF MELATONIN ON SPINAL CORD DAMAGE AFTER GAMMA IRRADIATION. JOURNAL OF DEVELOPMENTAL BIOLOGY, 1(3), 39-44. SID. https://sid.ir/paper/193156/en

Vancouver: Copy

MINAEE B., AGHAZADE S., AZARNIA M.. PROTECTIVE EFFECT OF MELATONIN ON SPINAL CORD DAMAGE AFTER GAMMA IRRADIATION. JOURNAL OF DEVELOPMENTAL BIOLOGY[Internet]. 2009;1(3):39-44. Available from: https://sid.ir/paper/193156/en

IEEE: Copy

B. MINAEE, S. AGHAZADE, and M. AZARNIA, “PROTECTIVE EFFECT OF MELATONIN ON SPINAL CORD DAMAGE AFTER GAMMA IRRADIATION,” JOURNAL OF DEVELOPMENTAL BIOLOGY, vol. 1, no. 3, pp. 39–44, 2009, [Online]. Available: https://sid.ir/paper/193156/en

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