A STUDY ON THE INHIBITORY EFFECTS OF TAXIFOLIN ON AMYLOID FIBRILLATION OF HEN EGG WHITE LYSOZYME

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MAHDAVIMEHR MOHSEN; MERATAN ALI AKBAR; BAGHERI ALI ASGHAR; KHOSRAVINEJAD FARIBA

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Journal: JOURNAL OF DEVELOPMENTAL BIOLOGY Year:2017 | Volume:9 | Issue:3 Page(s): 45-54

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Title

A STUDY ON THE INHIBITORY EFFECTS OF TAXIFOLIN ON AMYLOID FIBRILLATION OF HEN EGG WHITE LYSOZYME

Author(s)

MAHDAVIMEHR MOHSEN | MERATAN ALI AKBAR | BAGHERI ALI ASGHAR | KHOSRAVINEJAD FARIBA | Issue Writer Certificate

Keywords

AMYLOIDQ1

ATOMIC FORCE MICROSCOPYQ1

PROTEIN AGGREGATIONQ1

TAXIFOLINQ1

Abstract

Among therapeutic approaches for AMYLOID-related diseases, attention has recently turned to the use of natural products as effective anti-aggregation compounds. Although a wealth of in vitro and in vivo evidence indicates some common inhibitory activity of these compounds, they don’t generally suggest the same mechanism of action. In the present study, using a range of techniques including Thioflavin T and Nile red fluorescence assays, Congo red absorbance measurements, and ATOMIC FORCE MICROSCOPY the ability of TAXIFOLIN on the inhibition of HEWL AMYLOID fibrillation was investigated. Obtained results demonstrated that TAXIFOLIN exerts its inhibitory effect by binding to HEWL prefibrillar species. Furthermore, it’s binding results in diverting the AMYLOID pathway toward formation of very large globular, chain-like aggregates with low β-sheet content and reduced solvent-exposed hydrophobic patches. ThT fluorescence measurements show that the binding capacity of TAXIFOLIN is significantly reduced, upon generation of large protofibrillar aggregates at the end of growth phase. We believe these results may help design promising inhibitors of PROTEIN AGGREGATION for AMYLOID-related diseases.

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APA: Copy

MAHDAVIMEHR, MOHSEN, MERATAN, ALI AKBAR, BAGHERI, ALI ASGHAR, & KHOSRAVINEJAD, FARIBA. (2017). A STUDY ON THE INHIBITORY EFFECTS OF TAXIFOLIN ON AMYLOID FIBRILLATION OF HEN EGG WHITE LYSOZYME. JOURNAL OF DEVELOPMENTAL BIOLOGY, 9(3 ), 45-54. SID. https://sid.ir/paper/193190/en

Vancouver: Copy

MAHDAVIMEHR MOHSEN, MERATAN ALI AKBAR, BAGHERI ALI ASGHAR, KHOSRAVINEJAD FARIBA. A STUDY ON THE INHIBITORY EFFECTS OF TAXIFOLIN ON AMYLOID FIBRILLATION OF HEN EGG WHITE LYSOZYME. JOURNAL OF DEVELOPMENTAL BIOLOGY[Internet]. 2017;9(3 ):45-54. Available from: https://sid.ir/paper/193190/en

IEEE: Copy

MOHSEN MAHDAVIMEHR, ALI AKBAR MERATAN, ALI ASGHAR BAGHERI, and FARIBA KHOSRAVINEJAD, “A STUDY ON THE INHIBITORY EFFECTS OF TAXIFOLIN ON AMYLOID FIBRILLATION OF HEN EGG WHITE LYSOZYME,” JOURNAL OF DEVELOPMENTAL BIOLOGY, vol. 9, no. 3 , pp. 45–54, 2017, [Online]. Available: https://sid.ir/paper/193190/en

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