INVESTIGATION OF MEXX GENE IN PSEUDOMONAS AERUGINOSA ISOLATED OF CLINICAL SAMPLES

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ZOLALI M.; SALEHI M.; MOSAVARI N.; BOLFIUN M.; TAHERI M.; MIRZAEI M.

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Journal: JOURNAL OF MICROBIOLOGY KNOWLEDGE Year:2010 | Volume:2 | Issue:6 Page(s): 1-6

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Title

INVESTIGATION OF MEXX GENE IN PSEUDOMONAS AERUGINOSA ISOLATED OF CLINICAL SAMPLES

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Keywords

PSEUDOMONAS AERUGINOSAQ3

MEXX GENEQ3

DRUG RESISTANCEQ3

Abstract

PSEUDOMONAS AERUGINOSA is a nosocomial pathogen naturally recalcitrant to many antibiotics. Over the past decade, it has been realized that this poor drug susceptibility in part relies on the activity of active efflux system, namely MexXY-OprM. The MexXY-OprM system is unique in P. aeruginosa in that the mexXY operon is induced by exposure to many of the antibiotics that this efflux system exports. It is interesting that not all antibiotic substrates, but only those agents known to target the ribosome, induce mexXY expression.102 isolates collected from burn hospital and 58 isolates identified as PSEUDOMONAS AERUGINOSA .The isolates were identified by biochemical tests and then Susceptibility to antibiotics was performed. The MDR isolates selected for PCR and MICs determination. The most percentage of resistance to gentamicin, tobramycin, amikacin and ciprofloxacin observed. Presence of MEXX GENE demonstrated in MDR(multidrug resistant) starins. According to the observation about presence of MEXX GENE of MexXY-OprM system, we concluded that in these clinical isolates it was probably high expression of MexXY-OprM. Since the results of drug profiling suggested the expression of the MexXY–OprM efflux.

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APA: Copy

ZOLALI, M., SALEHI, M., MOSAVARI, N., BOLFIUN, M., TAHERI, M., & MIRZAEI, M.. (2010). INVESTIGATION OF MEXX GENE IN PSEUDOMONAS AERUGINOSA ISOLATED OF CLINICAL SAMPLES. JOURNAL OF MICROBIOLOGY KNOWLEDGE, 2(6), 1-6. SID. https://sid.ir/paper/193208/en

Vancouver: Copy

ZOLALI M., SALEHI M., MOSAVARI N., BOLFIUN M., TAHERI M., MIRZAEI M.. INVESTIGATION OF MEXX GENE IN PSEUDOMONAS AERUGINOSA ISOLATED OF CLINICAL SAMPLES. JOURNAL OF MICROBIOLOGY KNOWLEDGE[Internet]. 2010;2(6):1-6. Available from: https://sid.ir/paper/193208/en

IEEE: Copy

M. ZOLALI, M. SALEHI, N. MOSAVARI, M. BOLFIUN, M. TAHERI, and M. MIRZAEI, “INVESTIGATION OF MEXX GENE IN PSEUDOMONAS AERUGINOSA ISOLATED OF CLINICAL SAMPLES,” JOURNAL OF MICROBIOLOGY KNOWLEDGE, vol. 2, no. 6, pp. 1–6, 2010, [Online]. Available: https://sid.ir/paper/193208/en

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