COMPARATIVE EFFECTS OF OMEPRAZOLE AND CAPTOPRIL ON CYSTEAMINE INDUCED DUODENAL ULCER ON RAT

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SAGHAEI F.; SAMINI M.; KARIMI I.; KOOHPAYE A.

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Journal: JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN Year:2010 | Volume:7 | Issue:2 Page(s): 239-247

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Title

COMPARATIVE EFFECTS OF OMEPRAZOLE AND CAPTOPRIL ON CYSTEAMINE INDUCED DUODENAL ULCER ON RAT

Author(s)

SAGHAEI F. | SAMINI M. | KARIMI I. | KOOHPAYE A. | Issue Writer Certificate

Keywords

CYSTEAMINEQ2

DUODENAL ULCERQ3

CAPTOPRILQ3

OMEPRAZOLEQ2

RATQ2

Abstract

CYSTEAMINE is known to induce DUODENAL ULCER by oxidative effect in mucus. We studied the protective effect of CAPTOPRIL (with doses 15, 30 and 45 mg/kg respectively at 0.5 and 12 h before ulcer induction) and omeprazol (with doses 10, 20 and 30 mg/kg respectively at 0.5 and 12 h before ulcer induction) against CYSTEAMINE-induced DUODENAL ULCER (450 mg/kg twice at 4 h interval) in 112 RATs by determining DUODENAL ULCER Index and ulcer inhibition percent. Drugs used in this study were given by gavages. Twenty-four hours after the final dose of normal saline or CYSTEAMINE, the animals were killed under ether anesthesia and the duodena were excised carefully. Each duodenum was cut open along the antimesentric side and rinsed with saline and examined under 5-fold binocular magnification. For histological examination, tissue samples were fixed in 10% neutral buffered formalin. We found that CAPTOPRIL and OMEPRAZOLE decreased the incidence of ulcers and also enhanced the healing of ulcers. Ulcer Index by CYSTEAMINE was 3.02±0.6 but after the administration of Omeprazol decreased to 0.94±0.24 and with CAPTOPRIL reached to 0.7±0.24 that both was significant (P£0.05). Percent of ulcer inhibition by Omeprazol %68.74±8.24 and by CAPTOPRIL administration were %77.6±8.24. Conclusively, both drugs have antiulcer effects that are probably due to antioxidant effects of these drugs.

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APA: Copy

SAGHAEI, F., SAMINI, M., KARIMI, I., & KOOHPAYE, A.. (2010). COMPARATIVE EFFECTS OF OMEPRAZOLE AND CAPTOPRIL ON CYSTEAMINE INDUCED DUODENAL ULCER ON RAT. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, 7(2), 239-247. SID. https://sid.ir/paper/197335/en

Vancouver: Copy

SAGHAEI F., SAMINI M., KARIMI I., KOOHPAYE A.. COMPARATIVE EFFECTS OF OMEPRAZOLE AND CAPTOPRIL ON CYSTEAMINE INDUCED DUODENAL ULCER ON RAT. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN[Internet]. 2010;7(2):239-247. Available from: https://sid.ir/paper/197335/en

IEEE: Copy

F. SAGHAEI, M. SAMINI, I. KARIMI, and A. KOOHPAYE, “COMPARATIVE EFFECTS OF OMEPRAZOLE AND CAPTOPRIL ON CYSTEAMINE INDUCED DUODENAL ULCER ON RAT,” JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, vol. 7, no. 2, pp. 239–247, 2010, [Online]. Available: https://sid.ir/paper/197335/en

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