CYTOTOXIC ACTIVITY OF PEGYLATED NANOLIPOSOMAL HYDROXYUREA IN MCF-7 CELL LINE

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ALAVI SEYED EBRAHIM; KOOHI MOFTAKHARI ESFAHANI MAEDEH; AKBARZADEH AZIM

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2014 | Volume:4 | Issue:13 Page(s): 33-36

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Title

CYTOTOXIC ACTIVITY OF PEGYLATED NANOLIPOSOMAL HYDROXYUREA IN MCF-7 CELL LINE

Author(s)

ALAVI SEYED EBRAHIM | KOOHI MOFTAKHARI ESFAHANI MAEDEH | AKBARZADEH AZIM | Issue Writer Certificate

Keywords

NANO TECHNOLOGYQ2

DRUG DELIVERYQ2

BREAST CANCERQ1

PEGYLATED LIPOSOMALQ2

HYDROXYUREAQ2

Abstract

Aim and Background: Annually, BREAST CANCER takes the life of thousands of people. Nowadays, nanotechnology is the major topics of scientific societies in targeted pharmacy field. The nanotechnology helps control time, position and velocity of drug release. HYDROXYUREA is used as medicine in BREAST CANCER treatment, although it has side effects. Because of this, in order to reduce side effects, increase the efficiency and comfort patients the nano DRUG DELIVERY is used.Materials and methods: Certain ratios of Phosphatidylcholine, cholesterol and polyethylene glycol 2000 were synthesized and then the HYDROXYUREA drug was added. The mean diameter of pegylated nanoliposomal HYDROXYUREA was measured with the Zeta sizer device. Encapsulation efficiency and the pattern of drug release from pegylated nanoliposomes have been studied using spectrophotometry and dialysis methods. The cytotoxicity effect of the nanoliposomal drug was also measured by the MTT assay.Results: The mean diameter of pegylated nanoliposomal HYDROXYUREA was estimated 338.2 nanometers. Its encapsulation efficiency was 64.212±0.173 percent. The pattern of drug release from pegylated nanoliposomal drug within 28 hours was 25.85%. Results of this investigation also showed that the cytotoxic property of pegylated nanoliposomal HYDROXYUREA was 38.93% more than standard HYDROXYUREA.Conclusion: Polyethylene glycol demonstrated the increasing solubility of drug and in turn its better contact with the target cells.

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APA: Copy

ALAVI, SEYED EBRAHIM, KOOHI MOFTAKHARI ESFAHANI, MAEDEH, & AKBARZADEH, AZIM. (2014). CYTOTOXIC ACTIVITY OF PEGYLATED NANOLIPOSOMAL HYDROXYUREA IN MCF-7 CELL LINE. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 4(13), 33-36. SID. https://sid.ir/paper/204371/en

Vancouver: Copy

ALAVI SEYED EBRAHIM, KOOHI MOFTAKHARI ESFAHANI MAEDEH, AKBARZADEH AZIM. CYTOTOXIC ACTIVITY OF PEGYLATED NANOLIPOSOMAL HYDROXYUREA IN MCF-7 CELL LINE. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2014;4(13):33-36. Available from: https://sid.ir/paper/204371/en

IEEE: Copy

SEYED EBRAHIM ALAVI, MAEDEH KOOHI MOFTAKHARI ESFAHANI, and AZIM AKBARZADEH, “CYTOTOXIC ACTIVITY OF PEGYLATED NANOLIPOSOMAL HYDROXYUREA IN MCF-7 CELL LINE,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 4, no. 13, pp. 33–36, 2014, [Online]. Available: https://sid.ir/paper/204371/en

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