EVALUATING THE EFFECT OF NANOLIPOSOMAL HYDROXYUREA UREA ON THE BREAST CANCER CELL LINE

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ALAVI SEYED EBRAHIM; KOOHI MOFTAKHARI ESFAHANI MAEDEH; CHIANI MOHSEN; HEIDARINASAB AMIR; AKBARZADEH AZIM

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2013 | Volume:3 | Issue:11 Page(s): 63-67

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Title

EVALUATING THE EFFECT OF NANOLIPOSOMAL HYDROXYUREA UREA ON THE BREAST CANCER CELL LINE

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Keywords

BREAST CANCERQ1

NANO DRUG DELIVERYQ2

HYDROXYUREAQ2

LIPOSOMALQ2

Abstract

Aim and Background: Based on confirmed reports, it is clear that BREAST CANCER is one of the most prevalent diseases among women. HYDROXYUREA is one of the important drugs used in chemotherapy. despite its therapeutic propertie, this drug has many adverse effects in long-term, this study was performed in order to use the NANO DRUG DELIVERY technology using liposomes drug delivery for reducing the adverse effects and increasing therapeutic index as well.Materials and methods: A certain ratio of Phosphatidylinositol choline and cholesterol was synthesized in order to prepare the nanoliposome followed by adding the HYDROXYUREA drug. The mean diameter of nanoliposomal HYDROXYUREA was determined by zeta sizer system. The percent of drug released from liposome was performed by dialysis. Also, encapsulation efficiency of nanoliposomal HYDROXYUREA was calculated. Ultimately the cytotoxicity of formulation was probed by MTT assay.Results: The mean diameter of nanoliposome HYDROXYUREA and also and its encapsulation efficiency were recorded 402.5 nanometers and 70.836 % respectively. The pattern of drug release from nanoliposomes using dialysis method showed that the drug release of nanoliposome drug within 28 hours was equal to 25.85 %.Conclusion: This study showed that the cytotoxicity effect of nanoliposomal drug is more than that of the released drug.

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APA: Copy

ALAVI, SEYED EBRAHIM, KOOHI MOFTAKHARI ESFAHANI, MAEDEH, CHIANI, MOHSEN, HEIDARINASAB, AMIR, & AKBARZADEH, AZIM. (2013). EVALUATING THE EFFECT OF NANOLIPOSOMAL HYDROXYUREA UREA ON THE BREAST CANCER CELL LINE. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 3(11), 63-67. SID. https://sid.ir/paper/204649/en

Vancouver: Copy

ALAVI SEYED EBRAHIM, KOOHI MOFTAKHARI ESFAHANI MAEDEH, CHIANI MOHSEN, HEIDARINASAB AMIR, AKBARZADEH AZIM. EVALUATING THE EFFECT OF NANOLIPOSOMAL HYDROXYUREA UREA ON THE BREAST CANCER CELL LINE. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2013;3(11):63-67. Available from: https://sid.ir/paper/204649/en

IEEE: Copy

SEYED EBRAHIM ALAVI, MAEDEH KOOHI MOFTAKHARI ESFAHANI, MOHSEN CHIANI, AMIR HEIDARINASAB, and AZIM AKBARZADEH, “EVALUATING THE EFFECT OF NANOLIPOSOMAL HYDROXYUREA UREA ON THE BREAST CANCER CELL LINE,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 3, no. 11, pp. 63–67, 2013, [Online]. Available: https://sid.ir/paper/204649/en

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