BIOCHEMICAL MARKERS METHOD FOR DIAGNOSTIC OF TUBERCULOSIS IN THE PLEURAL SAMPLES FROM IRANIAN PATIENT

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ZAKER BOSTANABAD S.; KHOSRAVANI D.; GHALAMI M.; RAHIMI M.K.; FALLAH I.; ANSARI H.

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2011 | Volume:1 | Issue:1 Page(s): 45-52

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Title

BIOCHEMICAL MARKERS METHOD FOR DIAGNOSTIC OF TUBERCULOSIS IN THE PLEURAL SAMPLES FROM IRANIAN PATIENT

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Keywords

ADENOSINE DEAMINASEQ3

ISOENZYMEQ3

INTERFERONγQ3

TUBERCULOUS PLEURAL EFFUSIONQ3

Abstract

Aim and Background: To compare the diagnostic efficiency of ADENOSINE DEAMINASE, ISOENZYME ADENOSINE DEAMINASE-2 and concentration of interferon-g in patients with TUBERCULOUS PLEURAL EFFUSION.Materials and Methods: The prospective study was done on 114 patients who were divided into 3 groups: tuberculous, non-tuberculous infectious pleurisy, and malignant effusion. The ADENOSINE DEAMINASE, ADENOSINE DEAMINASE-2 and interferon-g were analyzed by receiver operating characteristic curves.Results: There was increase of all three markers in TUBERCULOUS PLEURAL EFFUSION but not in nontuberculous effusion. The cut-off values for ADENOSINE DEAMINASE, ADENOSINE DEAMINASE-2 and interferon-g were 40, 26 U/l. and 299 pg/ml respectively. ADENOSINE DEAMINASE, ADENOSINE DEAMINASE-2 activities were significantly higher in tuberculous effusion than in malignant pleural effusion (more than5 times) and in non-tuberculous infectious pleurisy (more than 4 times). The median of interferon-g concentration in pleural fluid of tuberculous patients was 1514.2 pg/ml (931.2-2187.5 pg/ml) which was 10 times more than the median values of other groups of patients. There was no significant difference between patients with malignant effusion and those with non-tuberculous pleural effusion.Conclusions: ADA and ADA2 in pleural is a marker for diagnostic of pleural effusion and all three markers had higher diagnostic yield for tuberculous effusion with 95% sensitivity.

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APA: Copy

ZAKER BOSTANABAD, S., KHOSRAVANI, D., GHALAMI, M., RAHIMI, M.K., FALLAH, I., & ANSARI, H.. (2011). BIOCHEMICAL MARKERS METHOD FOR DIAGNOSTIC OF TUBERCULOSIS IN THE PLEURAL SAMPLES FROM IRANIAN PATIENT. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 1(1), 45-52. SID. https://sid.ir/paper/204403/en

Vancouver: Copy

ZAKER BOSTANABAD S., KHOSRAVANI D., GHALAMI M., RAHIMI M.K., FALLAH I., ANSARI H.. BIOCHEMICAL MARKERS METHOD FOR DIAGNOSTIC OF TUBERCULOSIS IN THE PLEURAL SAMPLES FROM IRANIAN PATIENT. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2011;1(1):45-52. Available from: https://sid.ir/paper/204403/en

IEEE: Copy

S. ZAKER BOSTANABAD, D. KHOSRAVANI, M. GHALAMI, M.K. RAHIMI, I. FALLAH, and H. ANSARI, “BIOCHEMICAL MARKERS METHOD FOR DIAGNOSTIC OF TUBERCULOSIS IN THE PLEURAL SAMPLES FROM IRANIAN PATIENT,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 1, no. 1, pp. 45–52, 2011, [Online]. Available: https://sid.ir/paper/204403/en

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