DIAGNOSTIC VALUE OF SERUM ADENOSINE DEAMINASE AND ITS ISOENZYMES IN THE DIAGNOSIS OF PULMONARY TUBERCULOSIS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

JOUSHAGHANI H.R.; GHAEMI E.A.; NIK NEZHAD F.; TAVILANI H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2008 | Volume:9 | Issue:4 (24) Page(s): 41-48

Download Full-Text

Persian Verion

View:

2,066

Download:

Cites:

Information Journal Paper

Title

DIAGNOSTIC VALUE OF SERUM ADENOSINE DEAMINASE AND ITS ISOENZYMES IN THE DIAGNOSIS OF PULMONARY TUBERCULOSIS

Author(s)

JOUSHAGHANI H.R. | GHAEMI E.A. | NIK NEZHAD F. | TAVILANI H. | Issue Writer Certificate

Keywords

TUBERCULOSISQ3

ADENOSINE DEAMINASEQ2

ADA2Q3

SPUTUM CULTUREQ3

Abstract

Background & Objective: ADENOSINE DEAMINASE is an enzyme which catalyses adenosine to Inosine. The determination of ADENOSINE DEAMINASE in body fluids is important for the diagnosis of TUBERCULOSIS. There are contradictory reports about the diagnostic value of serum ADENOSINE DEAMINASE in pulmonary TUBERCULOSIS. This study was set up to investigate the diagnostic value of serum ADENOSINE DEAMINASE and its isoenzymes activities on pulmonary TUBERCULOSIS.Materials & Methods: In this descriptive study, blood samples were obtained from 26pulmonary TUBERCULOSIS patients (group 1), 17 suspected TUBERCULOSIS with negative in both smear and culture tests (group 2), and 67 healthy subjects (group 3). Total ADA and ADA2 determination was carried out by kinetic method and EHNA Inhibitor, respectively.Results: ADA and ADA2 activities are as follow: 19.35±5.04, 13.35±5.34 (group 1); 17.24±6.20, 11.47±3.92 (group 2) and 13.96±4.25, 7.36±2.91 (group 3). The mean differences of ADA and ADA2 activity between group 1 and 2 with group 3 was meaningful. The sensitivity and specificity for ADA and ADA2 tests were (26.9%, 94 %) and (50%, 97 %) respectively. The PPV for ADA and ADA2 were 63.6% and 86.7% and the NPV were 76.8% and 83.3%, respectively.Conclusion: This study indicated that the assessment of these enzymes in serum to some extend can be a useful method for differentiation of healthy subjects from respiratory disease, but these tests do not have enough sensitivity to assist in the diagnoses of TUBERCULOSIS patients from other respiratory diseases.

Cites

No record.

References

No record.

Cite

APA: Copy

JOUSHAGHANI, H.R., GHAEMI, E.A., NIK NEZHAD, F., & TAVILANI, H.. (2008). DIAGNOSTIC VALUE OF SERUM ADENOSINE DEAMINASE AND ITS ISOENZYMES IN THE DIAGNOSIS OF PULMONARY TUBERCULOSIS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 9(4 (24)), 41-48. SID. https://sid.ir/paper/401948/en

Vancouver: Copy

JOUSHAGHANI H.R., GHAEMI E.A., NIK NEZHAD F., TAVILANI H.. DIAGNOSTIC VALUE OF SERUM ADENOSINE DEAMINASE AND ITS ISOENZYMES IN THE DIAGNOSIS OF PULMONARY TUBERCULOSIS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2008;9(4 (24)):41-48. Available from: https://sid.ir/paper/401948/en

IEEE: Copy

H.R. JOUSHAGHANI, E.A. GHAEMI, F. NIK NEZHAD, and H. TAVILANI, “DIAGNOSTIC VALUE OF SERUM ADENOSINE DEAMINASE AND ITS ISOENZYMES IN THE DIAGNOSIS OF PULMONARY TUBERCULOSIS,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 9, no. 4 (24), pp. 41–48, 2008, [Online]. Available: https://sid.ir/paper/401948/en

Related Journal Papers