THE ROLES OF HMGB1 NUCLEAR PROTEIN AND ITS MAJOR DOMAINS INDIFFERENT BIOLOGICAL FIELDS

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TALEBI SOMAYEH; BOLHASSANI AZAM; MOKHTARI AZAD TALAT; ARASHKIA ARASH; MODARRESSI MOHAMMAD HOSSEIN

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2018 | Volume:8 | Issue:29 Page(s): 9-22

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Title

THE ROLES OF HMGB1 NUCLEAR PROTEIN AND ITS MAJOR DOMAINS INDIFFERENT BIOLOGICAL FIELDS

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Keywords

ENDOGENOUS ADJUVANTQ1

HMGB1Q1

HP91Q1

BIOLOGICAL ACTIVITYQ2

Abstract

HMGB1 protein is an intracellular protein that translocated into the nucleus and regulates genesexpression. HMGB1 plays multi-functional roles through recombination, transcriptional regulation, and inflammation. HMGB1 binds to cyclin-dependent kinase such as CDK2 that regulates thetranscription of genes associated with the progression of cell cycle. In addition, HMGB1 as a novelcytokine plays major role in inflammation and arthritis. Recently, the role of HMGB1 protein as anadjuvant and stimulating both humoral and cellular immune responses has been proven in viralinfections such as HIV-1 and influenza. Several studies indicated that HP91, a HMGB1-derivedpeptide, stimulates efficiently DC maturation, and boosts the cellular and humoral immuneresponses in vivo. Our recent data also showed that the full length of HMGB1 gene, and HP91peptide could be an effective adjuvant in developing the therapeutic HPV DNA-and protein-basedvaccines, respectively. In this review, the structure and functions of HMGB1 is described inmolecular biology and medicine.

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APA: Copy

TALEBI, SOMAYEH, BOLHASSANI, AZAM, MOKHTARI AZAD, TALAT, ARASHKIA, ARASH, & MODARRESSI, MOHAMMAD HOSSEIN. (2018). THE ROLES OF HMGB1 NUCLEAR PROTEIN AND ITS MAJOR DOMAINS INDIFFERENT BIOLOGICAL FIELDS. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 8(29 ), 9-22. SID. https://sid.ir/paper/204413/en

Vancouver: Copy

TALEBI SOMAYEH, BOLHASSANI AZAM, MOKHTARI AZAD TALAT, ARASHKIA ARASH, MODARRESSI MOHAMMAD HOSSEIN. THE ROLES OF HMGB1 NUCLEAR PROTEIN AND ITS MAJOR DOMAINS INDIFFERENT BIOLOGICAL FIELDS. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2018;8(29 ):9-22. Available from: https://sid.ir/paper/204413/en

IEEE: Copy

SOMAYEH TALEBI, AZAM BOLHASSANI, TALAT MOKHTARI AZAD, ARASH ARASHKIA, and MOHAMMAD HOSSEIN MODARRESSI, “THE ROLES OF HMGB1 NUCLEAR PROTEIN AND ITS MAJOR DOMAINS INDIFFERENT BIOLOGICAL FIELDS,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 8, no. 29 , pp. 9–22, 2018, [Online]. Available: https://sid.ir/paper/204413/en

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