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Information Journal Paper

Title

Effect of a 6-week Aerobic Exercise Program on High-mobility Group Box 1 Gene Expression in Aortic Tissue of Diabetic Rats

Pages

  82-97

Abstract

 Aims: Type 2 Diabetes is a rising problem and a significant risk factor for small and large vessel disease. The present study aims to investigate the effect of a 6-week aerobic exercise program on High-mobility Group Box 1 (HMGB1) gene expression in aortic tissue of diabetic rats. Methods & Materials: In this experimental study, 40 male rats aged 8 weeks were randomly selected. Once familiarized with the exercise protocol, they were divided into four groups of healthy-control (n=10), diabetic-control (n=10), healthy-exercise (n=10), and diabetic-exercise (n=10). Type 2 Diabetes was first induced, and then the rats run on a treadmill for 6 weeks, 5 sessions per week. After 12-14 h of fasting and 72 h after the last session, aortic tissue sampling was performed for HMGB1 analysis by quantitative realtime polymerase chain reaction (q-RT PCR) technique. Data analysis was performed using 1-way ANOVA and Tukey post hoc test at the significant level of P<0. 05. Findings: Induction of type 2 Diabetes led to a significant increase in HMGB1 gene expression in rats (P=0. 001), significantly reduced following aerobic exercise (P=0. 003). Aerobic exercise also reduced the expression of the HMGB1 gene in healthy rats (P=0. 000). Conclusion: Aerobic exercise may have a protective effect by reducing the HMGB1 gene expression in the aortic tissue of diabetic rats. It can be used as an effective non-pharmacological method to improve Diabetes-induced inflammation and prevent vascular disorders.

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    APA: Copy

    Hassanpour Soleimani, Samira, Abbassi Daloii, Asiyeh, Abdi, Ahmed, & Zilaei Bori, Sheerin. (2020). Effect of a 6-week Aerobic Exercise Program on High-mobility Group Box 1 Gene Expression in Aortic Tissue of Diabetic Rats. OFOGH-E-DANESH, 27(1 ), 82-97. SID. https://sid.ir/paper/409114/en

    Vancouver: Copy

    Hassanpour Soleimani Samira, Abbassi Daloii Asiyeh, Abdi Ahmed, Zilaei Bori Sheerin. Effect of a 6-week Aerobic Exercise Program on High-mobility Group Box 1 Gene Expression in Aortic Tissue of Diabetic Rats. OFOGH-E-DANESH[Internet]. 2020;27(1 ):82-97. Available from: https://sid.ir/paper/409114/en

    IEEE: Copy

    Samira Hassanpour Soleimani, Asiyeh Abbassi Daloii, Ahmed Abdi, and Sheerin Zilaei Bori, “Effect of a 6-week Aerobic Exercise Program on High-mobility Group Box 1 Gene Expression in Aortic Tissue of Diabetic Rats,” OFOGH-E-DANESH, vol. 27, no. 1 , pp. 82–97, 2020, [Online]. Available: https://sid.ir/paper/409114/en

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