NANO-PARTICLE DELIVERY OF SIRNA TO THE LUNG CANCER

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ASKARIAN SAEEDEH; OSKUEE REZA K.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2016 | Volume:6 | Issue:21 Page(s): 9-19

Download Full-Text

Persian Verion

View:

1,597

Download:

Cites:

Information Journal Paper

Title

NANO-PARTICLE DELIVERY OF SIRNA TO THE LUNG CANCER

Author(s)

ASKARIAN SAEEDEH | OSKUEE REZA K. | Issue Writer Certificate

Keywords

LUNG CANCERQ2

RNA INTERFERENCEQ2

NANO-PARTICLEQ2

DELIVERYQ1

Abstract

One of the common causes of cancer-related mortalities worldwide is LUNG CANCER and more than 1 million people annually die from it. LUNG CANCERs are divided into Non-small cell LUNG CANCER (NSCLC) and small cell lung carcinomas (SCLCs) which are different in several characteristics like biological behavior, response to therapy and genetic alterations.Resistance to conventional chemotherapy, especially in NSCLC patients is a major challenge in the treatment process. Therefore, development of novel therapeutic strategies is essential for improvement of survival rate. Combination of different therapeutic methods is an approach which can maximize efficiency of the treatment.Small interfering RNA (siRNA) has been reported to have a huge potential for the treatment or prevention of various lung diseases. Once the RNA molecules have successfully entered the target cells, they could inhibit the expression of specific gene sequence through RNA INTERFERENCE (RNAi) mechanism and generate therapeutic effects. The biggest obstacle to translating siRNA therapy from the laboratories into the clinics is DELIVERY. An ideal DELIVERY system should protect the siRNA from enzymatic degradation, facilitate cellular uptake and promote endosomal escape inside the cells, with negligible toxicity.Very limited work has been done on the formulation of siRNA for inhalation which is believed to be the direction for future development. This review article introduces LUNG CANCER and siRNA as a new treatment, and also studies the challenges of siRNA DELIVERY to lung cells by non-viral carriers. Furthermore, it surveyed some nano carriers for pulmonary siRNA DELIVERY with lipid, polymer and peptide basic.

Cites

No record.

References

No record.

Cite

APA: Copy

ASKARIAN, SAEEDEH, & OSKUEE, REZA K.. (2016). NANO-PARTICLE DELIVERY OF SIRNA TO THE LUNG CANCER. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 6(21), 9-19. SID. https://sid.ir/paper/204425/en

Vancouver: Copy

ASKARIAN SAEEDEH, OSKUEE REZA K.. NANO-PARTICLE DELIVERY OF SIRNA TO THE LUNG CANCER. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2016;6(21):9-19. Available from: https://sid.ir/paper/204425/en

IEEE: Copy

SAEEDEH ASKARIAN, and REZA K. OSKUEE, “NANO-PARTICLE DELIVERY OF SIRNA TO THE LUNG CANCER,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 6, no. 21, pp. 9–19, 2016, [Online]. Available: https://sid.ir/paper/204425/en

Related Journal Papers