COMPARISON OF XRCC1ARG399GLN POLYMORPHISM IN ENDOMETRIOSIS AND HEALTHY WOMEN

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SALEHIAN PIROOZ; HASSANI SEYYEDEH MASOUMEH; NADERI MARYAM; POOLADI ARASH

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2015 | Volume:5 | Issue:20 Page(s): 119-125

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Title

COMPARISON OF XRCC1ARG399GLN POLYMORPHISM IN ENDOMETRIOSIS AND HEALTHY WOMEN

Author(s)

SALEHIAN PIROOZ | HASSANI SEYYEDEH MASOUMEH | NADERI MARYAM | POOLADI ARASH | Issue Writer Certificate

Keywords

ARG399GLN POLYMORPHISMQ2

ENDOMETRIOSISQ2

PCR-RFLPQ1

XRCC1Q2

Abstract

Aim and Background: XRCC1 encods the protein involved in base excision repair (BER) system.Because of important role ofXRCC1 gene, polymorphism in this gene could increase the risk of many neoplasms in human. We conducted a research project to find out the association between ENDOMETRIOSIS with XRCC1polymorphism.Materials and Methods: In this cross sectional study 102 cases were enrolled. DNA was isolated from peripheral blood, and then genotyping of codon 399 ofXRCC1 was carried using specific primers and RFLP method.Results: Data from102 cases in an ENDOMETRIOSIS group (n=52) and a control group (n=50) were analyzed and led to the following results: the ARG399GLN POLYMORPHISM ofXRCC1 gene was 76.9% in the ENDOMETRIOSIS group compared with 28% in the control group (P=0.0001) with OR=2.47 and 95% CI: 1.72–4.39 (for GG vs. GA+AA) using Fisher’s exact test. Allelic Frequency on the ENDOMETRIOSIS group was 57.69% for G and 42.31% for A allele; these rates for the control group were 86% and 14% for G and A alleles respectively (P=0.0001).Conclusion: we came to the conclusion that arginine to glutamine polymorphism of XRCC1 gene codon 399 is associated with an increase in the risk of ENDOMETRIOSIS and obtained odd’s ratio indicates that people with this polymorphism have 2.47 times the risk of developing ENDOMETRIOSIS compared to people without polymorphism.

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APA: Copy

SALEHIAN, PIROOZ, HASSANI, SEYYEDEH MASOUMEH, NADERI, MARYAM, & POOLADI, ARASH. (2015). COMPARISON OF XRCC1ARG399GLN POLYMORPHISM IN ENDOMETRIOSIS AND HEALTHY WOMEN. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 5(20), 119-125. SID. https://sid.ir/paper/204452/en

Vancouver: Copy

SALEHIAN PIROOZ, HASSANI SEYYEDEH MASOUMEH, NADERI MARYAM, POOLADI ARASH. COMPARISON OF XRCC1ARG399GLN POLYMORPHISM IN ENDOMETRIOSIS AND HEALTHY WOMEN. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2015;5(20):119-125. Available from: https://sid.ir/paper/204452/en

IEEE: Copy

PIROOZ SALEHIAN, SEYYEDEH MASOUMEH HASSANI, MARYAM NADERI, and ARASH POOLADI, “COMPARISON OF XRCC1ARG399GLN POLYMORPHISM IN ENDOMETRIOSIS AND HEALTHY WOMEN,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 5, no. 20, pp. 119–125, 2015, [Online]. Available: https://sid.ir/paper/204452/en

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