GLN223ARG LEPTIN RECEPTOR GENETIC VARIATION IN WOMEN WITH UNEXPLAINED INFERTILITY AND FERTILE WOMEN

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ASHRAFI MAHABADI SHAMIM; TAFVIZI FARZANEH

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Journal: Journal of Sabzevar University of Medical Sciences Year:2018 | Volume:25 | Issue:2 Page(s): 127-134

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Information Journal Paper

Title

GLN223ARG LEPTIN RECEPTOR GENETIC VARIATION IN WOMEN WITH UNEXPLAINED INFERTILITY AND FERTILE WOMEN

Author(s)

ASHRAFI MAHABADI SHAMIM | TAFVIZI FARZANEH | Issue Writer Certificate

Keywords

GLN223ARG POLYMORPHISMQ1

UNEXPLAINED INFERTILITYQ1

Abstract

Background: UNEXPLAINED INFERTILITY refers to cases in which the standard diagnostic procedures available do not lead to a specific cause for the infertility. GLN223ARG POLYMORPHISM was associated with high serum leptin and consequently obesity, polycystic ovarian syndrome and infertility. The aim of this study was to investigate genetic variation of leptin receptor gene in unexplained infertile women.Materials and Methods: This case-control study was performed in 2015-2016. The subjects were 102 women with UNEXPLAINED INFERTILITY and 112 fertile women with normal hormone profile. All participants gave their signature in consent document. After an overnight fasting, 5 CC blood sample was drawn from all subjects in the day 3 of menstruation. Genotyping of GLN223ARG POLYMORPHISM was performed using RFLP-PCR technique.Results: No significant association was observed between GLN223ARG POLYMORPHISM and UNEXPLAINED INFERTILITY. The studied population was in Hardy-Weinberg equilibrium for GLN223ARG POLYMORPHISM. Therefore, there were not disturbing factors of Hardy-Weinberg equilibrium in the population.Conclusion In present study, LEPR GLN223ARG POLYMORPHISM is not a risk factor for women with UNEXPLAINED INFERTILITY. However, more studies on larger populations and the other leptin receptor polymorphism are suggested to understand the role of this polymorphism in women with UNEXPLAINED INFERTILITY.

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References

Genetic variation in leptin and leptin receptor genes as a risk factor for idiopathic male infertility

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APA: Copy

ASHRAFI MAHABADI, SHAMIM, & TAFVIZI, FARZANEH. (2018). GLN223ARG LEPTIN RECEPTOR GENETIC VARIATION IN WOMEN WITH UNEXPLAINED INFERTILITY AND FERTILE WOMEN. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 25(2 ), 127-134. SID. https://sid.ir/paper/81775/en

Vancouver: Copy

ASHRAFI MAHABADI SHAMIM, TAFVIZI FARZANEH. GLN223ARG LEPTIN RECEPTOR GENETIC VARIATION IN WOMEN WITH UNEXPLAINED INFERTILITY AND FERTILE WOMEN. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;25(2 ):127-134. Available from: https://sid.ir/paper/81775/en

IEEE: Copy

SHAMIM ASHRAFI MAHABADI, and FARZANEH TAFVIZI, “GLN223ARG LEPTIN RECEPTOR GENETIC VARIATION IN WOMEN WITH UNEXPLAINED INFERTILITY AND FERTILE WOMEN,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 2 , pp. 127–134, 2018, [Online]. Available: https://sid.ir/paper/81775/en

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