AN EVALUATION OF THE TRANSMEMBRANE AMMONIUM SULFATE GRADIENTSMETHOD IN LIPID SYSTEM TO IMPROVE TRAPPING CAPACITY OF AMPHIPATHICWEAK BASE DRUGS

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HAGHIRALSADAT BIBI FATEMEH; AMOABEDINY GHASEM; NADERINEZHAD SAMIRA; SHEIKHHA MOHAMMAD HASAN; MALAEI BALASI ZAHRA; AKBARZADEH AZIM; ZANDIEH DOULABI BEHROUZ

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2017 | Volume:7 | Issue:28 Page(s): 49-59

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Title

AN EVALUATION OF THE TRANSMEMBRANE AMMONIUM SULFATE GRADIENTSMETHOD IN LIPID SYSTEM TO IMPROVE TRAPPING CAPACITY OF AMPHIPATHICWEAK BASE DRUGS

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Keywords

PH GRADIENTQ1

DOXORUBICINQ1

LIPOSOMEQ1

PH SENSITIVEQ1

Abstract

Aim and Background: Liposomal vesicles provide the possibility of loading lipophilic drugs into phospholipids bilayersand water-soluble (hydrophilic) aqueous phase. The present study was aimed on the evaluation ofthe properties of liposomal DOXORUBICIN loaded into LIPOSOME by both active and passive proceduresin terms of drug loading and release. Material and methods: Dipalmitoyl glycerol phospholipid glycerol, cholesterol and DSPE-mPEG 2000 was used forsynthesis of nanoliposome. Then, DOXORUBICIN loading was performed by passive (thin filmhydration) and active (according to PH GRADIENT) methods. The average diameter of nanoparticlswas measured with Zeta Sizer. And the amount of drug loading and release was performed usingdialysis. Results: The average size of nanoparticles were 138. 6 ± 4. 9 nm and 105. 9 ± 3. 8 nm for thin film hydrationmethod, and PH GRADIENT method, respectively. And drug loading efficacy of DOXORUBICINcontainingnanoliposomes was 89± 4. 35 for PH GRADIENT method and 15. 65± 8. 65 for thin filmmethod. The accumulated amount of drug release during 48 hours in PBS at pH=7. 4, wasdetermined 78% and 24% for hydration thin film method PH GRADIENT method, respectively. Conclusion: This study shows that nanoliposomal DOXORUBICIN prepared by active method, was more effectivethan that the passive method. Our prepared nanoformulation was also sensitive to pH of medium.

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APA: Copy

HAGHIRALSADAT, BIBI FATEMEH, AMOABEDINY, GHASEM, NADERINEZHAD, SAMIRA, SHEIKHHA, MOHAMMAD HASAN, MALAEI BALASI, ZAHRA, AKBARZADEH, AZIM, & ZANDIEH DOULABI, BEHROUZ. (2017). AN EVALUATION OF THE TRANSMEMBRANE AMMONIUM SULFATE GRADIENTSMETHOD IN LIPID SYSTEM TO IMPROVE TRAPPING CAPACITY OF AMPHIPATHICWEAK BASE DRUGS. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 7(28 ), 49-59. SID. https://sid.ir/paper/204486/en

Vancouver: Copy

HAGHIRALSADAT BIBI FATEMEH, AMOABEDINY GHASEM, NADERINEZHAD SAMIRA, SHEIKHHA MOHAMMAD HASAN, MALAEI BALASI ZAHRA, AKBARZADEH AZIM, ZANDIEH DOULABI BEHROUZ. AN EVALUATION OF THE TRANSMEMBRANE AMMONIUM SULFATE GRADIENTSMETHOD IN LIPID SYSTEM TO IMPROVE TRAPPING CAPACITY OF AMPHIPATHICWEAK BASE DRUGS. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2017;7(28 ):49-59. Available from: https://sid.ir/paper/204486/en

IEEE: Copy

BIBI FATEMEH HAGHIRALSADAT, GHASEM AMOABEDINY, SAMIRA NADERINEZHAD, MOHAMMAD HASAN SHEIKHHA, ZAHRA MALAEI BALASI, AZIM AKBARZADEH, and BEHROUZ ZANDIEH DOULABI, “AN EVALUATION OF THE TRANSMEMBRANE AMMONIUM SULFATE GRADIENTSMETHOD IN LIPID SYSTEM TO IMPROVE TRAPPING CAPACITY OF AMPHIPATHICWEAK BASE DRUGS,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 7, no. 28 , pp. 49–59, 2017, [Online]. Available: https://sid.ir/paper/204486/en

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