Evaluation of the relationship between different polymorphisms of vitamin D receptor gene and renal diseases in patients with type 2 diabetes in Khuzestan province

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Jahanpour Ezatollah; Sazgar Hosein; DOOSTI ABBAS

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2019 | Volume:9 | Issue:36 Page(s): 97-107

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Title

Evaluation of the relationship between different polymorphisms of vitamin D receptor gene and renal diseases in patients with type 2 diabetes in Khuzestan province

Author(s)

Jahanpour Ezatollah | Sazgar Hosein | DOOSTI ABBAS | Issue Writer Certificate

Keywords

PolymorphismQ2

the vitamin D receptorQ1

nephropathyQ1

type 2 diabetesQ1

Abstract

Aim and Background: The purpose of this study was to investigate the association between different Polymorphisms of the vitamin D receptor coding gene (Taq1, Bsm1, Apa1, Fok1) with renal disease in patients with type 2 diabetes. Material and methods: In this case-control study, blood samples were taken from 50 healthy controls and 50 type 2 diabetic patients as control and 50 type 2 diabetic patients with nephropathy. Then, SSP-PCR technique was used to determine the different genotypes of vitamin D receptor Polymorphisms and the results were analyzed by SPSS 22 software. Results: In type 2 diabetic patients with Bb (64%) genotypes were the most frequent genotypes for Bsm1 Polymorphism, FF (54%) for Fok1, Aa (84%) for Apa1 and TT (36%) for Taq1. In addition, the probability of nephropathy with bb genotype (P-Value = 0. 007, OR = 6. 7730) for Bsm1 Polymorphism, ff genotype (OR = infinity and P-Value = 0. 01) for Fok1 Polymorphism, Aa genotype (OR) = 5. 25 and P-Value <0. 001) for Apa1 Polymorphism and tt genotype (OR = 5. 41, P-Value = 0. 003) for Taq1 Polymorphism increased. Conclusion: Genotypic frequency of Bsm1, Apa1, Fok1 and Taq1 Polymorphisms is related to the incidence of renal disease (nephropathy) in type 2 diabetic patients. However, the correlation between different Polymorphisms and the incidence of kidney disease shows that Apa1 Polymorphism has the greatest effect on renal complications in patients with type 2 diabetes. In addition, Bsm1 Polymorphism has the highest effect on the incidence of type 2 diabetes.

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APA: Copy

Jahanpour, Ezatollah, Sazgar, Hosein, & DOOSTI, ABBAS. (2019). Evaluation of the relationship between different polymorphisms of vitamin D receptor gene and renal diseases in patients with type 2 diabetes in Khuzestan province. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 9(36 ), 97-107. SID. https://sid.ir/paper/204522/en

Vancouver: Copy

Jahanpour Ezatollah, Sazgar Hosein, DOOSTI ABBAS. Evaluation of the relationship between different polymorphisms of vitamin D receptor gene and renal diseases in patients with type 2 diabetes in Khuzestan province. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2019;9(36 ):97-107. Available from: https://sid.ir/paper/204522/en

IEEE: Copy

Ezatollah Jahanpour, Hosein Sazgar, and ABBAS DOOSTI, “Evaluation of the relationship between different polymorphisms of vitamin D receptor gene and renal diseases in patients with type 2 diabetes in Khuzestan province,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 9, no. 36 , pp. 97–107, 2019, [Online]. Available: https://sid.ir/paper/204522/en

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