ASSOCIATION STUDY BETWEEN RS731236 POLYMORPHISMS OF VDR GENE AND DIABETIC NEPHROPATHY TYPE 2 AT IRANIAN POPULATION

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ARSHADI MASHKANI MARZIEH; MOHAMMAD AMOLI MAHSA; SALAHSHORIFAR IMAN; RAZI FARIDEH

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Journal: Iranian Journal of Diabetes and Metabolism Year:2017 | Volume:16 | Issue:3 Page(s): 165-172

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Title

ASSOCIATION STUDY BETWEEN RS731236 POLYMORPHISMS OF VDR GENE AND DIABETIC NEPHROPATHY TYPE 2 AT IRANIAN POPULATION

Author(s)

ARSHADI MASHKANI MARZIEH | MOHAMMAD AMOLI MAHSA | SALAHSHORIFAR IMAN | RAZI FARIDEH | Issue Writer Certificate

Keywords

TYPE 2 DIABETESQ1

DIABETIC NEPHROPATHYQ2

VITAMIN D RECEPTOR GENE (VDR)Q1

GENOTYPEQ2

POLYMORPHISM TAQ1Q1

Abstract

Background: Diabetes is the most common endocrine disorder that affects many people every year. DIABETIC NEPHROPATHY is main complication of diabetes type 2. Renoprotective effects of vitamin “D” in chronic kidney disease have been reported that including DIABETIC NEPHROPATHY. The purpose of this study is to investigate the association between polymorphism (rs731236 (Taq1)) at gene receptor vitamin D (VDR), and the risk of DIABETIC NEPHROPATHY in patients with TYPE 2 DIABETES.MethodsIn this case-control study, 104 patients with TYPE 2 DIABETES and nephropathy, 100 patients with TYPE 2 DIABETES and no nephropathy, and 98 people without diabetes and nephropathy who referred to the Diabetes Clinic of Tehran University of Medical Sciences were included. Clinical data were obtained and biochemical parameters were measured. The DNA samples were extracted from blood samples by phenol chloroform method. TheTaqI polymorphism (rs731236) was studied by TaqMan specific GENOTYPEs.Results: Urea, creatinine and urine albumin values were significantly higher and glomerular filtration rate was lower in nephropathy group. Although frequency of TT GENOTYPE and also T allele was higher in nephropathy group, the difference was not significant.Conclusion: There was no association between Taq1 polymorphism and DIABETIC NEPHROPATHY in the studied population.

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APA: Copy

ARSHADI MASHKANI, MARZIEH, MOHAMMAD AMOLI, MAHSA, SALAHSHORIFAR, IMAN, & RAZI, FARIDEH. (2017). ASSOCIATION STUDY BETWEEN RS731236 POLYMORPHISMS OF VDR GENE AND DIABETIC NEPHROPATHY TYPE 2 AT IRANIAN POPULATION. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 16(3 ), 165-172. SID. https://sid.ir/paper/54058/en

Vancouver: Copy

ARSHADI MASHKANI MARZIEH, MOHAMMAD AMOLI MAHSA, SALAHSHORIFAR IMAN, RAZI FARIDEH. ASSOCIATION STUDY BETWEEN RS731236 POLYMORPHISMS OF VDR GENE AND DIABETIC NEPHROPATHY TYPE 2 AT IRANIAN POPULATION. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2017;16(3 ):165-172. Available from: https://sid.ir/paper/54058/en

IEEE: Copy

MARZIEH ARSHADI MASHKANI, MAHSA MOHAMMAD AMOLI, IMAN SALAHSHORIFAR, and FARIDEH RAZI, “ASSOCIATION STUDY BETWEEN RS731236 POLYMORPHISMS OF VDR GENE AND DIABETIC NEPHROPATHY TYPE 2 AT IRANIAN POPULATION,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 16, no. 3 , pp. 165–172, 2017, [Online]. Available: https://sid.ir/paper/54058/en

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