DRUG DELIVERY OF PEGYLATED NANOLIPOSOMAL PACLITAXEL TO BREAST CANCER CELL LINE

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KOOHI MOFTAKHARI ESFAHANI MAEDEH; ALAVI SEYED EBRAHIM; ALAVI FATEMEH; GHAFERI MOHSEN; AKBARZADEH AZIM

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2014 | Volume:4 | Issue:14 Page(s): 47-50

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Title

DRUG DELIVERY OF PEGYLATED NANOLIPOSOMAL PACLITAXEL TO BREAST CANCER CELL LINE

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Keywords

POLYETHYLENE GLYCOLQ1

LIPOSOMEQ1

PACLITAXELQ2

NANOQ2

Abstract

Aim and Background: Formulation of anticancer drugs aroused intensive research in the past decades. Pegylated NANOliposomes have been utilized as effective drug carriers, a vehicle for drug delivery. The aim of this study is to evaluate the performance of POLYETHYLENE GLYCOL on the LIPOSOME structure.Materials and Methods: In order to produce pegylated NANOliposomal certain proportions of phosphatidylcholine, cholesterol, POLYETHYLENE GLYCOL and PACLITAXEL were mixed together. The mean diameter of pegylated NANOliposomal PACLITAXEL was determined by Zeta sizer system. The encapsulation efficiency was calculated using standard curve. The percent of drug released from pegylated NANOliposomes was performed by dialysis for 28 hours. Also, cytotoxicity of pegylated NANOliposomal PACLITAXEL was studied through MTT technique.Results: The particles’ mean diameter confirmed in NANO dimensions. Encapsulation efficiency and drug release of pegylated NANOliposomal PACLITAXEL was 95.2±6.3% and 5.02, respectively. Results showed an increase in toxicity, the formulation was prepared POLYETHYLENE GLYCOL causes more stability and slower release of drug.

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APA: Copy

KOOHI MOFTAKHARI ESFAHANI, MAEDEH, ALAVI, SEYED EBRAHIM, ALAVI, FATEMEH, GHAFERI, MOHSEN, & AKBARZADEH, AZIM. (2014). DRUG DELIVERY OF PEGYLATED NANOLIPOSOMAL PACLITAXEL TO BREAST CANCER CELL LINE. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 4(14), 47-50. SID. https://sid.ir/paper/204542/en

Vancouver: Copy

KOOHI MOFTAKHARI ESFAHANI MAEDEH, ALAVI SEYED EBRAHIM, ALAVI FATEMEH, GHAFERI MOHSEN, AKBARZADEH AZIM. DRUG DELIVERY OF PEGYLATED NANOLIPOSOMAL PACLITAXEL TO BREAST CANCER CELL LINE. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2014;4(14):47-50. Available from: https://sid.ir/paper/204542/en

IEEE: Copy

MAEDEH KOOHI MOFTAKHARI ESFAHANI, SEYED EBRAHIM ALAVI, FATEMEH ALAVI, MOHSEN GHAFERI, and AZIM AKBARZADEH, “DRUG DELIVERY OF PEGYLATED NANOLIPOSOMAL PACLITAXEL TO BREAST CANCER CELL LINE,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 4, no. 14, pp. 47–50, 2014, [Online]. Available: https://sid.ir/paper/204542/en

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