THE EFFECT OF CHITOSAN NANOPARTICLES CONTAINING PACLITAXEL ON DESTRUCTION OF BREAST CANCER CELLS

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RASANEH SAMIRA; SALEHI ZAHABI SALEH

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Journal: Journal of Clinical Research in Paramedical Sciences Year:2016 | Volume:4 | Issue:4 Page(s): 311-317

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Title

THE EFFECT OF CHITOSAN NANOPARTICLES CONTAINING PACLITAXEL ON DESTRUCTION OF BREAST CANCER CELLS

Author(s)

RASANEH SAMIRA | SALEHI ZAHABI SALEH | Issue Writer Certificate

Keywords

PACLITAXOLQ2

CHITOSAN NANOPARTICLESQ2

DRUG DELIVERYQ2

BREAST CANCERQ2

Abstract

Background: Paclitaxel is a new chemotherapy medicine that is used for treating breast, ovarian, and lung cancers as well as AIDS related Kaposi's sarcoma. Due to the side effects of using this drug, the paclitaxel-loaded CHITOSAN NANOPARTICLES was synthesized and its cytotoxicity effects on BREAST CANCER cell lines was examined.Methods: The paclitaxel-loaded CHITOSAN NANOPARTICLES were synthesized by the gelation method, purified and isolated in a proper size by centrifugation. The nanoparticles’ size, percentage of loading and releasing time of the drug up to 24 hours and its cytotoxicity effects, compared with Paclitaxel; on BREAST CANCER cell lines were investigated.Results: Particle sizes revealed to be 248-312 nm using the zetasizer system, the drug loading percentage showed 55±4 %, and the rate of drug releasing time for 24 h measured 5.5 %. On the average in concentration of 0.8 mg/mL the cytotoxicity of the PACLITAXOL-loaded CHITOSAN NANOPARTICLES was estimated 43% less than that of the taxol.Conclusion: The results showed that the PACLITAXOL-loaded CHITOSAN NANOPARTICLES may be considered as a good alternative to taxol since it decreases the related side effects. However, it deserves further investigations in future.

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APA: Copy

RASANEH, SAMIRA, & SALEHI ZAHABI, SALEH. (2016). THE EFFECT OF CHITOSAN NANOPARTICLES CONTAINING PACLITAXEL ON DESTRUCTION OF BREAST CANCER CELLS. JOURNAL OF CLINICAL RESEARCH IN PARAMEDICAL SCIENCES, 4(4), 311-317. SID. https://sid.ir/paper/256019/en

Vancouver: Copy

RASANEH SAMIRA, SALEHI ZAHABI SALEH. THE EFFECT OF CHITOSAN NANOPARTICLES CONTAINING PACLITAXEL ON DESTRUCTION OF BREAST CANCER CELLS. JOURNAL OF CLINICAL RESEARCH IN PARAMEDICAL SCIENCES[Internet]. 2016;4(4):311-317. Available from: https://sid.ir/paper/256019/en

IEEE: Copy

SAMIRA RASANEH, and SALEH SALEHI ZAHABI, “THE EFFECT OF CHITOSAN NANOPARTICLES CONTAINING PACLITAXEL ON DESTRUCTION OF BREAST CANCER CELLS,” JOURNAL OF CLINICAL RESEARCH IN PARAMEDICAL SCIENCES, vol. 4, no. 4, pp. 311–317, 2016, [Online]. Available: https://sid.ir/paper/256019/en

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