THE COMPARISON OF REVERSE PHASE EVAPORATION AND ETHER INJECTION SYNTHESIS METHODS ON CISPLATIN-LOADED NIOSOMAL NANOPARTICLES PROPERTIES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

BABAEI MAHROKH; HASANZADEGAN ROUDSARI MAJID; RASHIDI NILOFAR; ARDJMAND MEHDI; AKBARZADEH AZIM

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2016 | Volume:6 | Issue:22 Page(s): 59-64

Download Full-Text

Persian Verion

View:

918

Download:

Cites:

Information Journal Paper

Title

THE COMPARISON OF REVERSE PHASE EVAPORATION AND ETHER INJECTION SYNTHESIS METHODS ON CISPLATIN-LOADED NIOSOMAL NANOPARTICLES PROPERTIES

Author(s)

Keywords

DRUG DELIVERYQ1

CISPLATINQ1

NIOSOMEQ1

MTTQ1

C6 CELL LINEQ1

Abstract

Aim and Background: Nowadays, using nanocarriers has increased in DRUG DELIVERY industry. NIOSOME is one of the nanocarriers with non-ionic surfactant which increases the stability of drug in body. Since, using CISPLATIN in the treatment of cancers has some side effects, it was nanoniosomed.Materials and Methods: Nanoniosomes were synthesized by reverse phase evaporation and ether injection methods. The mean diameter of particles was determined using Zetasizer. The encapsulation and drug loading efficiency of two formulations which were prepared from both reverse phase evaporation and ether injection methods was measured by spectrophotometric method. Drug release pattern was examined by dialysis in a period of 48 hours. Cytotoxicity effect on nanoniosomal CISPLATIN was determined on C6 CELL LINE by MTT assay.Results: The mean diameter of particles was synthesized by reverse phase evaporation and ether injection methods was determined 242.1±5.10 nm and 218.6±3.42 nm, respectively. The encapsulation and drug loading efficiency of two formulations were measured 43.6±4.59%, 52.8±3.22%; 4.36±0.08% and 5.28±0.17%, respectively. The results of drug release showed that released drug from prepared formulation using reverse phase evaporation was 97.53±0.55% and using ether injection was 81.23±1.24%. In addition, the results of cytotoxicity showed that the cytotoxicity of prepared formulation using ether injection more than prepared formulation applying reverse phase evaporation.Conclusion: This study showed that using reverse phase evaporation to synthesize nanoniosomal CISPLATIN is more appropriate method than ether that of injection method.

Cites

No record.

References

No record.

Cite

APA: Copy

BABAEI, MAHROKH, HASANZADEGAN ROUDSARI, MAJID, RASHIDI, NILOFAR, ARDJMAND, MEHDI, & AKBARZADEH, AZIM. (2016). THE COMPARISON OF REVERSE PHASE EVAPORATION AND ETHER INJECTION SYNTHESIS METHODS ON CISPLATIN-LOADED NIOSOMAL NANOPARTICLES PROPERTIES. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 6(22), 59-64. SID. https://sid.ir/paper/204623/en

Vancouver: Copy

BABAEI MAHROKH, HASANZADEGAN ROUDSARI MAJID, RASHIDI NILOFAR, ARDJMAND MEHDI, AKBARZADEH AZIM. THE COMPARISON OF REVERSE PHASE EVAPORATION AND ETHER INJECTION SYNTHESIS METHODS ON CISPLATIN-LOADED NIOSOMAL NANOPARTICLES PROPERTIES. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2016;6(22):59-64. Available from: https://sid.ir/paper/204623/en

IEEE: Copy

MAHROKH BABAEI, MAJID HASANZADEGAN ROUDSARI, NILOFAR RASHIDI, MEHDI ARDJMAND, and AZIM AKBARZADEH, “THE COMPARISON OF REVERSE PHASE EVAPORATION AND ETHER INJECTION SYNTHESIS METHODS ON CISPLATIN-LOADED NIOSOMAL NANOPARTICLES PROPERTIES,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 6, no. 22, pp. 59–64, 2016, [Online]. Available: https://sid.ir/paper/204623/en

Related Journal Papers